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Comment & Response |

Bioprosthetic Valves for Transcatheter Aortic Valve Replacement

Michael J. Reardon, MD1
[+] Author Affiliations
1Department of Cardiothoracic Surgery, Houston Methodist DeBakey Heart and Vascular Center, Houston, Texas
JAMA. 2014;312(8):844-845. doi:10.1001/jama.2014.8364.
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To the Editor The CHOICE trial1 is the first randomized trial comparing balloon-expandable and self-expandable valves for TAVR. This trial used the VARC definition of device success as a composite primary end point. It found a higher device success with the balloon-expandable valve, driven largely by a lower frequency of aortic regurgitation. There are several serious flaws in the trial design that call these conclusions into question.


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August 27, 2014
Mohamed Abdel-Wahab, MD; Julinda Mehilli, MD; Gert Richardt, MD
1Heart Center, Segeberger Kliniken, Bad Segeberg, Germany
2Munich University Clinic, Munich, Germany
JAMA. 2014;312(8):845-846. doi:10.1001/jama.2014.8375.
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