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Comment & Response |

Statins and Ischemic Stroke—Reply

Paul Muntner, PhD1; George Howard, DrPh2; Monika M. Safford, MD3
[+] Author Affiliations
1Department of Epidemiology, University of Alabama, Birmingham
2Department of Biostatistics, University of Alabama, Birmingham
3Department of Medicine, University of Alabama, Birmingham
JAMA. 2014;312(7):750. doi:10.1001/jama.2014.8367.
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In Reply Based on published studies,13 we think there are clear benefits for statins for the primary and secondary prevention of stroke. The Cholesterol Treatment Trialists’ Collaboration4 meta-analysis from 2010 showed a hazard ratio of 0.85 (95% CI, 0.80-0.90) for stroke per 1-mmol/L reduction of low-density lipoprotein cholesterol with statin use vs placebo; 0.80 (99% CI, 0.73-0.88) for ischemic stroke, 1.10 (99% CI, 0.86-1.42) for hemorrhagic stroke, and 0.88 (99% CI, 0.76-1.02) for unknown stroke type. Although heterogeneity between primary and secondary prevention trials was not reported, similar patterns appeared to be present for primary and secondary prevention trials.

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August 20, 2014
J. David Spence, MD, FRCPC
1Robarts Research Institute, Western University, London, Ontario, Canada
JAMA. 2014;312(7):749-750. doi:10.1001/jama.2014.8357.
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