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Comment & Response |

Statins and Ischemic Stroke

J. David Spence, MD, FRCPC1
[+] Author Affiliations
1Robarts Research Institute, Western University, London, Ontario, Canada
JAMA. 2014;312(7):749-750. doi:10.1001/jama.2014.8357.
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To the Editor The report from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study1 indicated that the new equations for predicting atherosclerotic cardiovascular risk appeared to overestimate the risk of atherosclerotic events in the participants. This study affords an opportunity to assess a possible problem with the new Pooled Cohort risk equations.

The accompanying Editorial2 emphasized underascertainment of events in the observational REGARDS study as a likely reason for apparent overestimation of risk and raised the possibility that statin therapy in participants may have reduced outcomes compared with the prediction by the equations.


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August 20, 2014
Paul Muntner, PhD; George Howard, DrPh; Monika M. Safford, MD
1Department of Epidemiology, University of Alabama, Birmingham
2Department of Biostatistics, University of Alabama, Birmingham
3Department of Medicine, University of Alabama, Birmingham
JAMA. 2014;312(7):750. doi:10.1001/jama.2014.8367.
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