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Tadalafil for Erectile Dysfunction Prevention After Radiotherapy for Prostate Cancer

Fabio Castiglione, MD1; Francesco Montorsi, MD1; Alberto Briganti, MD1
[+] Author Affiliations
1Division of Oncology, IRCCS Ospedale San Raffaele, Milan, Italy
JAMA. 2014;312(7):748. doi:10.1001/jama.2014.7920.
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To the Editor Dr Pisansky and colleagues1 did not find any beneficial effect of daily tadalafil administration in preventing erectile dysfunction (ED) in men treated with radiotherapy for prostate cancer. Concerns about the methodology of this study parallel those raised after previous trials testing penile rehabilitation after radical prostatectomy. These include inadequate patient selection,1 short-term follow-up,2 and possibly improper tadalafil administration.3


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August 20, 2014
Thomas M. Pisansky, MD; Deborah W. Bruner, PhD, RN; Richard E. Greenberg, MD
1Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota
2Emory University, Atlanta, Georgia
3Fox Chase Cancer Center, Philadelphia, Pennsylvania
JAMA. 2014;312(7):748-749. doi:10.1001/jama.2014.7923.
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