Author Contributions: Drs Holme and Løberg had full access to all data and take responsibility for the integrity of the data and the accuracy of the data analysis. Drs Holme and Løberg contributed equally.
Study concept and design: Hoff, Bretthauer, Eide, Skovlund, Schneede, Tveit.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Holme.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Holme, Løberg, Kalager, Hernán.
Obtained funding: Hoff, Kalager, Løberg, Holme, Bretthauer, Hernán.
Study supervision: Hoff.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Bretthauer reports being a member of the European scientific advisory board of Exact Sciences and receipt of equipment for testing in scientific studies from Olympus, Fujinon, Falk Pharma and CCS Healthcare. No other disclosures were reported.
Funding/Support: The NORCCAP trial was funded by research grants from the Norwegian government and the Norwegian Cancer Society. Work with the present article was funded by research grants from the Norwegian Cancer Society, the Research Council of Norway, The South-East Regional Health Authority of Norway, The Fulbright Foundation, Sorlandet Hospital Kristiansand, and the National Institutes of Health grant PO1 CA134294.
Role of the Sponsors: The funding organizations had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
NORCCAP Collaborators: Per Efskind MD, Nedre Glommen Physicians, Fredrikstad, Norway; Ghous Gondal MD PhD, Østfold Hospital, Fredrikstad, Norway; Gert Huppertz-Hauss MD, Telemark Hospital, Skien, Norway; Bjørn Hofstad MD PhD, Oslo University Hospital, Oslo, Norway; Solveig Thorp Holmsen MD MPH, Oslo University Hospital, Oslo, Norway; Inger Kristin Larsen PhD, Cancer Registry of Norway, Oslo, Norway; Volker Moritz MD, Telemark Hospital, Skien, Norway; Sverre Nyhus MD, Vestfold Hospital, Tonsberg, Norway; Espen Thiis-Evensen MD PhD, Oslo University Hospital, Oslo, Norway; Tom Grotmol MD Professor, Cancer Registry of Norway, Oslo, Norway. The NORCCAP steering committee comprises Geir Hoff MD Professor, Cancer Registry of Norway, Oslo and Telemark Hospital, Skien, Norway; Eva Skovlund Professor, School of Pharmacy, University of Oslo, Oslo, Norway; Morten Vatn MD Professor, Oslo University Hospital, Oslo, Norway; Tor Iversen Professor, University of Oslo, Oslo, Norway; Jørn Schneede MD Professor, Umeå University, Umeå, Sweden; Michael Bretthauer MD Professor, Oslo University Hospital and University of Oslo, Oslo, Norway; Kjell Magne Tveit MD Professor, Oslo University Hospital, Oslo, Norway; Jon Lekven MD Professor, University of Bergen, Bergen, Norway and Tor Jac Eide MD Professor, University of Oslo and Oslo University Hospital, Oslo, Norway. Dedicated nurses and staff at the screening centers made this trial possible.
The NORCCAP Data and Safety Monitoring Committee: Hans-Olov Adami, MD, Harvard School of Public Health, Boston, Massachusetts, and Karolinska Institutet, Stockholm, Sweden; Sandra J Lee, ScD, Harvard Medical School and Dana-Farber Cancer Institute, Boston, Massachusetts; and Douglas K Rex, MD, Indiana University School of Medicine, Indianapolis.
Correction: This article was corrected on August 12, 2014, for mismatched author affiliations, incorrect company name in the Disclosures paragraph, and accuracy of the title of Figure 4.