Study concept and design: Nuotio, Hartikainen, Airaksinen.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Nuotio, Hartikainen, Biancari, Airaksinen.
Critical revision of the manuscript for important intellectual content: Nuotio, Hartikainen, Grönberg, Airaksinen.
Statistical analysis: Nuotio, Grönberg, Biancari.
Obtained funding: Hartikainen, Airaksinen.
Administrative, technical, or material support: Hartikainen, Airaksinen.
Study supervision: Hartikainen, Airaksinen.
Conflict of Interest Disclosures: The authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest and none were reported.
Funding/Support: This research was supported by the Finnish Foundation for Cardiovascular Research (Helsinki, Finland), and the Clinical Research Fund of Turku University Hospital (Turku, Finland).
Role of the Sponsor: The Finnish Foundation for Cardiovascular Research and the Clinical Research Fund of Turku University Hospital had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Disclaimer: The findings and conclusions of this report are those of the authors and do not necessarily represent the official position of the the Finnish Foundation for Cardiovascular Research or the Clinical Research Fund of Turku University Hospital.
Trial Registration: clinicaltrials.gov Identifier: NCT01380574