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Comment & Response |

Age-Adjusted D-Dimer Cutoff Levels and Pulmonary Embolism

Giorgio Colombo, MS1; Ludovico Furlan, MD1; Giulia Colombo, MS1
[+] Author Affiliations
1Divisione di Medicina ad Indirizzo Fisiopatologico, Ospedale L.Sacco, Milano, Italy
JAMA. 2014;312(5):557. doi:10.1001/jama.2014.7604.
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To the Editor The study by Dr Righini and colleagues1 validated the use of an age-adjusted D-dimer cutoff level to rule out pulmonary embolism. The 6 different D-dimer assays used in the study were demonstrated to be equivalent in a previous meta-analysis.2

Nevertheless, we noticed that there was a significant difference among the assays in the proportion of negative results, considering both standard and age-adjusted D-dimer cutoff levels.

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August 6, 2014
Marc Righini, MD; Pieter W. Kamphuisen, MD, PhD; Grégoire Le Gal, MD, PhD
1Division of Angiology and Hemostasis, Geneva University Hospital and Faculty of Medicine, Geneva, Switzerland
2Department of Vascular Medicine, University of Groningen, Groningen, the Netherlands
3Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
JAMA. 2014;312(5):557. doi:10.1001/jama.2014.7607.
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