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February 3, 1999, Vol 281, No. 5 >

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Grand Rounds | February 3, 1999

Infectious Mononucleosis in Middle Age

Paul G. Auwaerter, MD
JAMA. 1999;281(5):454-459. doi:10.1001/jama.281.5.454.
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Figure 1. Normal and Atypical Lymphocytes of Infectious Mononucleosis
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A, Normal-appearing lymphocyte with compact nucleus and little cytoplasm. B and C, Bizarrely shaped atypical lymphocytes of infectious mononucleosis. Most are enlarged and have increased basophilia and cytoplasm. The nucleus may be irregular or indented (B), with lightly staining chromatin. Cytoplasmic edges may be indented by other blood cells, leading to a scalloped appearance called Dutch skirting (arrow) (C). Unlike leukemic cells, atypical lymphocytes show extreme variability of size and shape.
Figure 2. EBV-Specific Serologic Responses in Infectious Mononucleosis
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Serologic responses to common Epstein-Barr virus (EBV) antigens after primary EBV infection. VCA indicates viral capsid antigen; EA, early antigen (diffuse [anti-D]); and EBNA, anti-EBV nuclear antigen. Figure adapted courtesy of the Scandinavian University Press.32

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