Study concept and design: Robertson, Hannay, Yamal, Gopinath, Valadka, Swank.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Robertson, Hannay, Yamal, Gopinath, Ahmed, Rubin, Benoit.
Critical revision of the manuscript for important intellectual content: Robertson, Yamal, Goodman, Tilley, Baldwin, Lara, Saucedo-Crespo, Sadasivan, Ponce, Cruz-Navarro, Shahin, Aisiku, Doshi, Valadka, Neipert, Waguspack, Swank.
Statistical analysis: Yamal, Tilley, Ahmed, Rubin, Benoit, Swank.
Obtained funding: Robertson, Hannay, Valadka.
Administrative, technical, or material support: Robertson, Hannay, Yamal, Gopinath, Goodman, Baldwin, Saucedo-Crespo, Sadasivan, Ponce, Cruz-Navarro, Shahin, Doshi.
Study supervision: Robertson, Hannay, Yamal, Gopinath, Shahin, Aisiku, Valadka.
Conflict of Interest Disclosures: The authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Drs Robertson and Doshi and Mr Waguspack reported receiving grants from National Institutes of Health, National Institute of Neurological Disorders and Stroke during the conduct of the study. None of the other authors reported any disclosures.
Funding/Support: This study was supported by grant P01-NS38660 from the National Institute of Neurological Disorders and Stroke.
Role of the Sponsors: The National Institute of Neurological Disorders and Stroke had no role in the design and conduct of the study; the collection, analysis, and interpretation of the data; in the preparation, review, or approval of the manuscript; or in the decision to submit the manuscript for publication.
Data and Safety Monitoring Committee: Charles Contant (chair), Ramon Diaz-Arrastia, Geoffrey Manley, Kyra Becker, Daniel Hanley.
Adult Respiratory Distress Syndrome Consensus Committee: Venkata Bandi, Imoigele P. Aisiku, Bradford Scott.
National Institute of Neurological Disorders and Stroke Project Scientist: Ramona Hicks.
Additional Contributions: We thank the staff of Ben Taub General Hospital and Memorial Hermann Hospital for their participation in the study. We also thank Michael O. Gonzalez, MS, and Xuemei Xi (both with the University of Texas School of Public Health) for programming in the Statistical Center; and Jeannie P. Tamez, PhD, Brenda Lopez, BA, Afife D. Batarse, BS, Larissa Gonzalez, BS, Laura O’Rosky, BS, and Michelle C. Munguia, BA (University of Houston), for their work in performing the outcome assessments. Each person listed received salary support from the grant funding the study.