We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Medical News & Perspectives |

New Method to Repair Faulty Genes Stirs Interest in Chimeraplasty Technique

Joan Stephenson, PhD
JAMA. 1999;281(2):119-121. doi:10.1001/jama.281.2.119.
Text Size: A A A
Published online


Scientists have developed a provocative new technique for correcting tiny but potentially devastating errors in mutant genes, an approach they hope will someday provide a strategy for treating at least some genetic disorders.

The approach, known as chimeraplasty or targeted gene correction, is still in its infancy and faces many technical challenges before it is clear whether the method can move from bench to bedside. Moreover, some skeptics say that a number of investigators have had difficulty getting the procedure to work and question whether the approach will be generally applicable to a variety of cell types.

Figures in this Article

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview


Place holder to copy figure label and caption

Cells from albino mice have a genetic mutation that prevents them from making an enzyme (tyrosinase) necessary to produce the black pigment melanin (left), but descendants of an albino cell with a tyrosinase gene successfully repaired by chimeraplasty are readily able to make melanin (right). Photo credit: Vitali Alexeev, PhD, and Kyonggeun Yoon, PhD

Graphic Jump Location



Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

6 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
PubMed Articles