0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Contempo 1999 |

Advances in the Treatment of Hypertension

Thomas G. Pickering, MD, DPhil
JAMA. 1999;281(2):114-116. doi:10.1001/jama.281.2.114.
Text Size: A A A
Published online

Extract

The past year has seen a flurry of publications of large-scale clinical trials that may have major impact on the treatment of hypertensive patients. Most of these appeared after the November 1997 publication of the latest report of the Joint National Committee (JNC VI)1 and generally support its recommendations.

The sixth report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure [published correction appears in Arch Intern Med. 1998;158:573]. Arch Intern Med.1997;157:2413-2446.
Appel LJ, Moore TJ, Obarzanek E.  et al. A clinical trial of the effects of dietary patterns on blood pressure: DASH Collaborative Research Group. N Engl J Med.1997;336:1117-1124.
de Lorgeril M, Salen P, Martin JL, Monjaud I, Boucher P, Mamelle N.Mediterranean dietary pattern in a randomized trial: prolonged survival and possible reduced cancer rate. Arch Intern Med.1998;158:1181-1187.
de Lorgeril M, Renaud S, Mamelle N.  et al. Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease. Lancet.1994;343:1454-1459.
Ascherio A, Rimm EB, Hernan MD.  et al. Intake of potassium, magnesium, calcium, and fiber and risk of stroke among US men. Circulation.1998;98:1198-1204.
Appel LJ, Espeland M, Whelton PK.  et al. Trial of Nonpharmacologic Intervention in the Elderly (TONE): design and rationale of a blood pressure control trial. Ann Epidemiol.1995;5:119-129.
Philipp T, Anlauf M, Distler A, Holzgreve H, Michaelis J, Wellek S.Randomised, double blind, multicentre comparison of hydrochlorothiazide, atenolol, nitrendipine, and enalapril in antihypertensive treatment: results of the HANE study: HANE Trial Research Group. BMJ.1997;315:154-159.
Hansson L, Hedner T, Lindholm LH.  et al. The Captopril Prevention Project (CAPPP) in hypertension: final results. J Hypertens.1998;16(suppl 2):S22.
Pahor M, Guralnick JM, Salivc ME, Corti M-C, Carbonin P, Havlik RJ.Do calcium channel blockers increase the risk of cancer? Am J Hypertens.1996;9:695-699.
Lever AF, Hole DJ, Gillis CR.  et al. Do inhibitors of angiotensin-I-converting enzyme protect against risk of cancer? Lancet.1998;352:179-184.
Hole DJ, Gillis CK, McCallum IR.  et al. Cancer risk of hypertensive patients taking calcium antagonists. J Hypertens.1998;16:119-124.
Messerli FH, Grossman E, Goldbourt U.Are beta-blockers efficacious as first-line therapy for hypertension in the elderly? a systematic review. JAMA.1998;279:1903-1907.
Pahor M, Shorr RI, Somes GW.  et al. Diuretic-based treatment and cardiovascular events in patients with mild renal dysfunction enrolled in the Systolic Hypertension in the Elderly Program. Arch Intern Med.1998;158:1340-1345.
Curb JD, Pressel SL, Cutler JA.  et al. Effect of diuretic-based antihypertensive treatment on cardiovascular disease risk in older diabetic patients with isolated systolic hypertension: Systolic Hypertension in the Elderly Program Cooperative Research Group [published correction appears in JAMA. 1996;277:1356]. JAMA.1996;276:1886-1892.
Staessen JA, Fagard R, Thijs L.  et al. Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension: the Systolic Hypertension in Europe (Syst-Eur) Trial Investigators. Lancet.1997;350:757-764.
Forette F, Seux M-L, Staessen J.  et al. Prevention of dementia in randomised double-blind placebo-controlled Systolic Hypertension in Europe (Syst-Eur) trial. Lancet.1998;352:1347-1351.
Estacio RO, Jeffers BW, Hiatt WR, Biggerstaff SL, Gifford N, Schrier RW.The effect of nisoldipine as compared with enalapril on cardiovascular outcomes in patients with non-insulin-dependent diabetes and hypertension. N Engl J Med.1998;338:645-652.
Tatti P, Pahor M, Byington RP.  et al. Outcome results of the Fosinopril Versus Amlodipine Cardiovascular Events Randomized Trial (FACET) in patients with hypertension and NIDDM. Diabetes Care.1998;21:597-603.
UK Prospective Diabetes Study Group. Efficacy ofatenolol and captopril in reducing risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 39. BMJ.1998;317:713-720.
Hansson L, Zanchetti A, Carruthers SG.  et al. Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial: HOT Study Group. Lancet.1998;351:1755-1762.
UK Prospective Diabetes Study Group. Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38. BMJ.1998;317:703-713.

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Letters

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Web of Science® Times Cited: 5

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();