Study concept and design: Nyboe Andersen, Pasternak, Svanström, Hviid, Jess.
Acquisition, analysis, or interpretation of data: Nyboe Andersen, Pasternak, Basit, Andersson, Caspersen, Munkholm, Jess.
Drafting of the manuscript: Nyboe Andersen, Jess.
Critical revision of the manuscript for important intellectual content: Pasternak, Basit, Andersson, Svanström, Caspersen, Munkholm, Hviid, Jess.
Statistical analysis: Nyboe Andersen, Basit, Andersson.
Obtained funding: Nyboe Andersen, Jess.
Administrative, technical, or material support: Nyboe Andersen, Munkholm, Jess.
Study supervision: Jess.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Nyboe Andersen reported receving travel funding and speakers fees from Merck Sharp and Dohme. Dr Munkholm reported serving on the advisory boards of Merck Sharp and Dohme, Tillotts, and Calpro Inc and receiving lecture fees from Ferring Inc and Tillotts. Dr Jess reported receiving travel funding and speakers fees from AbbVie. No other authors reported disclosures.
Funding/Support: This study was supported by grants from the Lundbeck Foundation (R83-A7812), the Danish Cancer Society (R40-A1737-11-S2), and the Crohn’s & Colitis Association of Denmark. Dr Jess holds a Female Research Leader grant (09-066323) from the Danish Council of Independent Research.
Role of the Sponsors: The finding organizations had no role in the design and conduct of the study; the collection, management, analysis, and interpretation of the data; the preparation, review, or approval of the manuscript; or the decision to submit the manuscript for publication.
Additional Contributions: We thank Jan Wohlfahrt, DMSc (Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark), for additional statistical support, which was provided without compensation.