A 1-year hospital-wide program severely restricting all cephalosporin
use was associated with a significant decrease in the incidence of cephalosporin-resistant Klebsiella infection and colonization compared with the
prior year. But, report Rahal and colleaguesArticle, the increased use of imipenem-cilastin
during the study period was associated with an increase in incidence of imipenem-resistant Pseudomonas aeruginosa. In an editorial, BurkeArticle comments
that optimal antibiotic use based on individual patient information might
achieve heterogeneity of antibiotic use, reduce unnecessary use, and help
stabilize antibiotic resistance.