We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Comment & Response |

Antihypertensive Therapy After Acute Ischemic Stroke

Simone Vidale, MD1; Claudio Pini, MD1; Marco Arnaboldi, MD1
[+] Author Affiliations
1Department of Neurology and Stroke Unit, Sant’Anna Hospital, Como, Italy
JAMA. 2014;311(22):2334. doi:10.1001/jama.2014.5164.
Text Size: A A A
Published online


To the Editor Dr He and colleagues1 reported no beneficial effects on death and major disability among patients with ischemic stroke who were promptly treated to reduce blood pressure. In previous studies, elevated blood pressure is present in about 80% of patients with ischemic stroke, and in the next few days a spontaneous decline often happens.2 Although elevated blood pressure contributes to a poor outcome, several trials have failed to demonstrate a clinical benefit of moderate to intensive blood pressure reduction during the acute phase.3 The mechanisms of this transitory elevation (eg, the increase in plasma catecholamines due to autonomic nervous system activation, the response to decreased focal cerebral perfusion, or the site of the brain lesion, especially brain stem4) are not well understood.


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview




June 11, 2014
Jiang He, MD, PhD; Yonghong Zhang, MD, PhD; Jing Chen, MD, MSc
1Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana
2School of Public Health, Medical College of Soochow University, Suzhou, China
3Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana
JAMA. 2014;311(22):2334-2335. doi:10.1001/jama.2014.5167.
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...