The global community that is dedicated to understanding, treating, and
preventing human immunodeficiency virus (HIV) infection is gathering in Geneva,
Switzerland, from June 28 through July 3, 1998, for the 12th International
Conference on AIDS (acquired immunodeficiency syndrome). Whereas steady incremental
advances characterized the field of HIV research throughout the first 10 international
conferences on AIDS, the 11th conference in Vancouver, British Columbia, focused
on quantum leaps within the areas of therapeutics (ie, introduction of protease
inhibitors for use in combination antiretroviral regimens) and pathogenesis
(ie, identification of chemokine receptors as HIV coreceptors). Early optimism
regarding the possibility of eradication of HIV has yielded to the more realistic
concept of long-term control of virus replication. In addition, the many obstacles
to effective therapy for persons with HIV infection highlight the theme of
2 years ago, "much accomplished, much to do."1
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