In this issue of THE JOURNAL, Downs et al1
present the primary results of the Air Force/Texas Coronary Atherosclerosis
Prevention Study (AFCAPS/TexCAPS). The study is yet another randomized, placebo-controlled,
clinical trial of a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase
inhibitor, in this case lovastatin, as a means to prevent atherosclerotic
coronary artery disease. Although readers might wonder what such a trial might
add to understanding the role of lipid-lowering therapy in general, or of
the use of the so-called statins in particular, this trial is of singular
importance and timeliness to guide the use of these agents in the controversial
area of the primary prevention of cardiovascular disease.
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