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Internal Medicine Harrison's Principles of Internal Medicine

JAMA. 1998;279(19):1578. doi:10.1001/jama.279.19.1578.
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There can't be too many of us old codgers left who remember the excitement that greeted the first edition of Tinsley Harrison's Principles of Internal Medicine in 1950. There even was a story in Time magazine about this innovative textbook of medicine. Different about Harrison's was a long section called "Cardinal Manifestations of Disease," a discussion of the differential diagnosis and pathophysiology of common presenting symptoms, signs, and syndromes. Previous textbooks had followed the format established by Osler: individual essays on specific disease entities. Harrison's was the first to help the reader confronted with the patient as he or she presented, unlabelled and without the diagnosis necessary to find information in the standard textbooks. This wonderful feature, now called "Cardinal Manifestations and Presentations of Disease," has continued through all 14 editions, in the new edition comprising over 300 pages, or slightly more than 12% of the text.


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