Context.— Contaminated pharmaceutical products can result in substantial morbidity
and mortality and should be included in the differential diagnosis of deaths
of unknown origin.
Objective.— To investigate an outbreak of deaths among children from acute renal
failure in Haiti to determine the etiology and institute control measures.
Design.— Case-control study, cohort study, and laboratory toxicologic evaluation.
Setting.— Pediatric population of Haiti.
Participants.— Cases were defined as Haitian residents younger than 18 years with idiopathic
anuria or severe oliguria for 24 hours or longer. Febrile hospitalized children
without renal failure were enrolled as control subjects.
Main Outcome Measure.— The odds of exposure to suspected etiologic agents among cases and controls.
Results.— We identified 109 cases of acute renal failure among children. The clinical
syndrome included renal failure, hepatitis, pancreatitis, central nervous
system impairment, coma, and death. Of 87 patients with follow-up information
who remained in Haiti for treatment, 85 (98%) died; 3 (27%) of 11 patients
transported to the United States for intensive care unit management died before
hospital discharge. A locally manufactured acetaminophen syrup was highly
associated with disease (odds ratio, 52.7; 95% confidence interval, 15.2-197.2).
Diethylene glycol (DEG) was found in patients' bottles in a median concentration
of 14.4%. The median estimated toxic dose of DEG was 1.34 mL/kg (range, 0.22-4.42
mL/kg). Glycerin, a raw material imported to Haiti and used in the acetaminophen
formulation, was contaminated with 24% DEG.
Conclusions.— An epidemic of severe systemic toxicity and deaths from DEG-contaminated
acetaminophen syrup occurred in Haiti. Good manufacturing practice regulations
should be used by all pharmaceutical manufacturers to prevent such tragedies.