Author Contributions: Dr Eng had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Bennett, Eng.
Acquisition of data: Bennett, Mester, Eng.
Analysis and interpretation of data: Bennett, Eng.
Drafting of the manuscript: Bennett, Eng.
Critical revision of the manuscript for important intellectual content: Bennett, Mester, Eng.
Statistical analysis: Bennett, Eng.
Administrative, technical, or material support: Mester.
Financial Disclosures: None reported.
Funding/Support: Dr Eng reports receipt of funding for this study, in part, by the Breast Cancer Research Foundation, the William Randolph Hearst Foundations, and the National Cancer Institute (P01CA124570). Dr Eng is the Sondra J. and Stephen R. Hardis Chair of Cancer Genomic Medicine at the Cleveland Clinic, was a Doris Duke Distinguished Clinical Scientist, and is an American Cancer Society Clinical Research Professor, which is funded, in part, by the FM Kirby Foundation.
Role of Sponsor: The Breast Cancer Research Foundation, William Randolph Hearst Foundations, and the National Cancer Institute had no role in the design and conduct of the study, in the collection, management, analysis, and interpretation of the data, or in the preparation of the manuscript.
Additional Contributions: We thank the patients who participated in this study and whose contribution made this work possible. We are grateful to members of the Eng lab for thoughtful discussions.