We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Health Agencies Update |

Rotavirus Vaccine

Bridget M. Kuehn
JAMA. 2010;304(24):2687. doi:10.1001/jama.2010.1816.
Text Size: A A A
Published online


The US Centers for Disease Control and Prevention (CDC) continues to recommend vaccination of infants with 2 rotavirus vaccines, Rotarix and RotaTeq, despite emerging reports from large clinical trials in other countries of a small risk of intussusception.

In September, the US Food and Drug Administration announced a change in the label for Rotarix to indicate an increased risk of intussusception among infants during the month after the first dose (http://tinyurl.com/25589oc). The information was based on preliminary data from a postmarketing trial of the vaccine in Mexico, which found an 1.8-fold increased risk of intussusception. On October 28, the CDC's Advisory Committee on Immunization Practices (ACIP) evaluated data from this trial and other postmarketing studies in Latin America and Australia that have suggested an increased risk of intussusception shortly after vaccination with Rotarix or RotaTeq. So far, a study of more than 800 000 doses of RotaTeq in the United States through the Vaccine Safety Datalink (a collaborative effort between the CDC and 8 managed care organizations) has not found an increased risk. The ACIP noted in a statement that if an increased risk of intussusception exists in the United States similar to that seen in the Mexican study, about 1 case of intussusception would occur per 100 000 US infants receiving the vaccine.

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
PubMed Articles