Published Online: November 15, 2010. doi:10.1001/jama.2010.1708
Author Contributions: Drs Zhan and Seliger had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: deFilippi, Gottdiener, Kop, Seliger.
Acquisition of data: Christenson, Gottdiener, Seliger.
Analysis and interpretation of data: deFilippi, de Lemos, Kop, Zhan, Seliger.
Drafting of the manuscript: deFilippi, Kop, Seliger.
Critical revision of the manuscript for important intellectual content: de Lemos, Christenson, Gottdiener, Kop, Zhan, Seliger.
Statistical analysis: Kop, Zhan, Seliger.
Obtained funding: deFilippi.
Administrative, technical, or material support: deFilippi, Christenson, Gottdiener.
Study supervision: deFilippi.
Financial Disclosures: Dr deFilippi reported receiving honorarium, consulting, and grant support from Roche Diagnostics and Siemens Healthcare Diagnostics, and consulting and grant support from Critical Diagnostics and BG Medicine. Dr de Lemos reported receiving research support from Biosite and Roche Diagnostics, and consulting fees, lecture honoraria, or both from Roche Diagnostics, Biosite/Inverness, and Siemens. Dr Christenson reported receiving research funding from Siemens Medical Diagnostics and Response Biomedical. Dr Seliger reported receiving grant and consulting support from Roche Diagnostics. Drs Gottdiener, Kop, and Zahn reported no financial disclosures.
Funding/Support: This study was supported by grants N01-HC-85079 through N01-HC-85086, N01-HC-35129, N01 HC-15103, N01 HC-55222, N01-HC-75150, N01-HC-45133, and U01 HL080295 from the National Heart, Lung, and Blood Institute (NHLBI), with additional contribution from the National Institute of Neurological Disorders and Stroke. Additional support was provided through R01 AG-15928, R01 AG-20098, and AG-027058 from the National Institute on Aging; R01 HL-075366 from the NHLBI; and the University of Pittsburgh Claude D. Pepper Older Americans Independence Center P30-AG-024827. Additional funding was provided by Roche Diagnostics. Roche Diagnostics provided funding and laboratory reagents for the highly sensitive cardiac troponin T assay.
Role of the Sponsor: The NHLBI was involved in the study planning and limited data management. This study was also critically reviewed and approved by the Cardiovascular Health Study steering committee before submission. Roche Diagnostics had no role in the design and conduct of the study, in the collection, management, analysis, and data interpretation, or in the preparation, review, or approval of the manuscript.
A full list of principal Cardiovascular Health Study investigators and institutions can be found at http://www.chs-nhlbi.org/pi.htm.