Author Contributions: Dr Abou-Alfa had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Abou-Alfa, Johnson, Knox, Saltz.
Acquisition of data: Abou-Alfa, Johnson, Knox, Davidenko, Lacava, Leung, Gansukh, Saltz.
Analysis and interpretation of data: Abou-Alfa, Johnson, Knox, Capanu, Davidenko, Lacava, Leung, Gansukh, Saltz.
Drafting of the manuscript: Abou-Alfa, Capanu, Saltz.
Critical revision of the manuscript for important intellectual content: Abou-Alfa, Johnson, Knox, Capanu, Davidenko, Lacava, Leung, Gansukh, Saltz.
Statistical analysis: Abou-Alfa, Capanu, Gansukh, Saltz.
Administrative, technical, or material support: Gansukh.
Study supervision: Abou-Alfa, Saltz.
Financial Disclosures: Drs Abou-Alfa, Johnson, Knox, Davidenko, Lacava, and Leung report receiving research support from and serving as consultants to Bayer. Dr Saltz reports receiving research support from Bayer. Dr Capanu and Ms Gansukh report no financial disclosures.
Funding/Support: This work was supported by a research grant from Bayer.
Role of the Sponsor: Representatives of Bayer contributed to the design, conduct of the study, and data collection.
Independent Statistical Analysis: The reported statistical analysis of the data was conducted independently from the sponsor by co-author Marinela Capanu, PhD, from the department of Epidemiology and Biostatistics at Memorial Sloan-Kettering Cancer Center. Dr Capanu received the entire raw data set and ran the analysis. Where needed, she also conducted sensitivity analyses as described. Dr Capanu was not compensated for this work.
Previous Presentations: Presented in part at the 14th European Cancer Conference of the European Cancer Organisation; September 23-27 2007; Barcelona, Spain, and at the Gastrointestinal Meeting of the American Society of Clinical Oncology; January 2008, Orlando, Florida.