Author Contributions: Dr Aaron had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Aaron, Vandemheen, Ramotar, Chan, Doucette, Fergusson.
Acquisition of data: Aaron, Vandemheen, Ramotar, Lewis-Giesbrecht, Tullis, Freitag, Paterson, Jackson, Lougheed, Kumar, Ferris, Chan.
Analysis and interpretation of data: Aaron, Vandemheen, Lewis-Giesbrecht, Dowson, Doucette, Fergusson.
Drafting of the manuscript: Aaron, Vandemheen, Lewis-Giesbrecht, Fergusson.
Critical revision of the manuscript for important intellectual content: Aaron, Vandemheen, Ramotar, Lewis-Giesbrecht, Tullis, Freitag, Paterson, Jackson, Lougheed, Dowson, Kumar, Ferris, Chan, Doucette, Fergusson.
Statistical analysis: Doucette, Fergusson.
Obtained funding: Aaron, Vandemheen, Lewis-Giesbrecht, Dowson, Chan, Fergusson.
Administrative, technical, or material support: Aaron, Vandemheen, Lewis-Giesbrecht, Freitag, Ferris, Chan.
Study supervision: Aaron, Vandemheen, Ramotar, Tullis, Freitag, Lougheed, Dowson.
Financial Disclosures: None reported.
Funding/Support: Funded by the Canadian Institutes of Health Research, the Canadian Cystic Fibrosis Foundation, and the Ontario Thoracic Society.
Role of the Sponsor: None of the sponsors or funders had any involvement in the design or conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript.
Additional Contributions: We thank Scott Bell, MD (Prince Charles Hospital, Brisbane, Queensland, Australia), for providing our study with Pseudomonas aeruginosa isolates from Australia, and Lesley Gaskin and Jennifer Pike (St Michael's Hospital, Toronto, Ontario, Canada), Ena Gaudet, RN, and Kathleen Devecseri, RN (Ottawa Hospital, Ottawa, Ontario, Canada), Rosamund Hennessey, RN (McMaster University, Hamilton, Ontario, Canada), Tracey Gooyers, RN, Patrice Kean, BScN, and Jennifer Itterman, BScN (University of Western Ontario, London, Ontario, Canada), Sharri-Lynne Zinger, RN, and Charlene Piche, RN (Sudbury Regional Hospital, Sudbury, Ontario, Canada), Lori Peterson, RN, BScN, MS (Grand River Hospital, Kitchener, Ontario, Canada), and Lisa Smith, RN, BScN, MSc (Queen's University, Kingston, Ontario, Canada) for study coordination. We also thank Lucie Hyde, MLT, Randy Wilson, BSc, MLT, Kellie Langill, and Sau-Wai Yeung (Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada) and Melissa St Denis, MSc (University of Calgary, Calgary, Alberta, Canada) for assistance with microbiology, and My-Linh Tran and Jennie Cote (Ottawa Hospital Research Institute, Ottawa, Ontario, Canada) for assistance with data management. None of the persons listed in this section were compensated for their contributions.