Author Contributions: Dr Rodondi had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Rodondi, Bauer, Cornuz, Westendorp, Gussekloo.
Acquisition of data: Rodondi, Bauer, Walsh, Åsvold, Iervasi, Imaizumi, Sgarbi, Khaw, Vanderpump, Newman, Franklyn, Westendorp, Gussekloo.
Analysis and interpretation of data: Rodondi, den Elzen, Bauer, Cappola, Razvi, Åsvold, Iervasi, Imaizumi, Collet, Bremner, Maisonneuve, Sgarbi, Cornuz, Franklyn, Westendorp, Vittinghoff, Gussekloo.
Drafting of the manuscript: Rodondi.
Critical revision of the manuscript for important intellectual content: den Elzen, Bauer, Cappola, Razvi, Walsh, Åsvold, Iervasi, Imaizumi, Collet, Bremner, Maisonneuve, Sgarbi, Khaw, Vanderpump, Newman, Cornuz, Franklyn, Westendorp, Vittinghoff, Gussekloo.
Statistical analysis: Rodondi, den Elzen, Bauer, Vittinghoff.
Obtained funding: Walsh, Iervasi, Sgarbi, Khaw, Vanderpump, Newman, Franklyn, Westendorp, Gussekloo.
Administrative, technical, or material support: Rodondi, Collet, Khaw, Newman, Gussekloo.
Study supervision: Rodondi, Westendorp, Gussekloo.
Financial Disclosures: None reported.
Funding/Support: The Cardiovascular Health Study and the research reported in this article were supported by contract numbers N01-HC-80007, N01-HC-85079 through N01-HC-85086, N01-HC-35129, N01 HC-15103, N01 HC-55222, N01-HC-75150, N01-HC-45133, grant number U01 HL080295 from the National Heart, Lung, and Blood Institute, with additional funding from the National Institute of Neurological Disorders and Stroke. Additional support was provided through grants R01 AG-15928, R01 AG-20098, AG-027058, and AG-032317 from the National Institute on Aging, grant R01 HL-075366 from the National Heart, Lung, and Blood Institute, and grant P30-AG-024827 from the University of Pittsburgh Claude. D. Pepper Older Americans Independence Center. A full list of principal investigators and institutions of the Cardiovascular Health Study can be found at http://www.chs-nhlbi.org/pi.htm. The thyroid measurements in the Cardiovascular Health Study were supported by an American Heart Association Grant-in-Aid (to Linda Fried). The Health, Aging, and Body Composition Study is supported by National Institute on Aging contract numbers N01-AG-6-2101, N01-AG-6-2103, and N01-AG-6-2106, and in part by the Intramural Research Program of the National Institutes of Health. The National Institute on Aging funded the Health Aging, and Body Composition study. The Leiden 85-plus Study was partly funded by the Dutch Ministry of Health, Welfare, and Sports. The Whickham Survey was supported by the UK Department of Health. The HUNT Study was a collaborative effort of the Faculty of Medicine, Norwegian University of Science and Technology, the Norwegian Institute of Public Health, and the Nord-Trøndelag County Council. The thyroid testing in the HUNT Study was financially supported by Wallac Oy (Turku, Finland). The Nagasaki Adult Health Study was supported by the Radiation Effects Research Foundation, Hiroshima and Nagasaki, Japan, a private, nonprofit foundation funded by the Japanese Ministry of Health, Labor and Welfare and the US Department of Energy, the latter in part through the National Academy of Sciences. This publication was supported by research protocol A-10-08 from the Radiation Effects Research Foundation. The EPIC-Norfolk study was supported by research grants from the UK Medical Research Council and the UK Cancer Research. The Brazilian Thyroid Study was supported by an unrestricted grant from the Sao Paulo State Research Foundation (Fundacão de Amparo a" Pesquisa do Estado de Sao Paulo grant 6/59737-9 to Rui Maciel). Dr Newman is supported by grant AG-023629 from the the National Institute on Aging. Dr Westendorp is supported by grant NGI/NWO 911-03-016 from the Netherlands Organization for Scientific Research.
Role of the Sponsor: The majority of the sponsors had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; or preparation, review, or approval of the manuscript. The National Institute on Aging funded the Health, Aging, and Body Composition study and reviewed the manuscript and approved its publication. The Radiation Effects Research Foundation funded the Nagasaki Adult Health Study and reviewed the manuscript and approved its publication.
Statistical Evaluation: Dr Vittinghoff, professor of biostatistics, in the Department of Epidemiology and Biostatistics, University of California, San Francisco, reviewed the statistical analyses of the article.
Participating Studies of the Thyroid Studies Collaboration:United States: Cardiovascular Health Study; Health, Aging, and Body Composition Study. The Netherlands: the Leiden 85-plus Study. Australia: Busselton Health Study. United Kingdom: Whickham Survey; Birmingham Study; EPIC-Norfolk Study. Italy: Pisa Cohort. Japan: Nagasaki Adult Health Study. Brazil: Brazilian Thyroid Study. Norway: Nord-Trøndelag Health Study (HUNT Study).
Additional Contributions: We thank Sabrina Molinaro (Clinical Physiology Institute, Pisa, Italy) for technical help about data from the Pisa Cohort and from Rui Maciel (Escola Paulista de Medicina, Federal University of Sao Paulo, Brazil) for technical help about data from the Brazilian Thyroid Study. The persons listed in this section did not receive financial compensation.