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JAMA Clinical Challenge |

A Child With a White Pupil QUIZ

Najim Lahrouchi, MD1; Machteld I. Bosscha, MD1; Annette C. Moll, MD, PhD1
[+] Author Affiliations
1Department of Ophthalmology, VU University Medical Center, Amsterdam, the Netherlands
JAMA. 2014;311(17):1799-1800. doi:10.1001/jama.2013.286248.
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Figure 1.

Patient at presentation with leukocoria (abnormal white pupillary reflection).

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Figure 2.

A, Funduscopic examination showing a large subretinal white tumor (blue arrowhead) and total retinal detachment (white arrowhead). B, Axial T2-weighted magnetic resonance image shows a total retinal detachment with subretinal hemorrhage (white arrowhead). The retina is diffusely infiltrated by retinoblastoma (blue arrowhead). C, Histology showing tumor invasion through the lamina cribrosa (dashed line) into the postlaminar optic nerve but without reaching the margin of resection. Arrowhead indicates the choroid (hematoxylin-eosin, original magnification ×5).

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