Author Contributions: Dr Neoptolemos had full access to all the data in the study and takes full responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Neoptolemos, Stocken, Bassi, Ghaneh, Cunningham, Moore, Friess, Dervenis, Büchler.
Acquisition of data: Neoptolemos, Bassi, Cunningham, Goldstein, Padbury, Gallinger, Mariette, Wente, Izbicki, Lerch, Dervenis, Oláh, Butturini, Doi, Lind, Smith, Palmer, Buckels, Thompson, McKay, Rawcliffe, Büchler.
Analysis and interpretation of data: Neoptolemos, Stocken, Bassi, Ghaneh, Goldstein, Moore, Izbicki, Dervenis, Doi, Lind, Valle, Büchler.
Drafting of the manuscript: Neoptolemos, Stocken, Ghaneh, Goldstein, Wente, Dervenis, Oláh, Buckels, Rawcliffe, Büchler.
Critical revision of the manuscript for important intellectual content: Neoptolemos, Stocken, Bassi, Cunningham, Goldstein, Padbury, Moore, Gallinger, Mariette, Wente, Izbicki, Friess, Lerch, Dervenis, Butturini, Doi, Lind, Smith, Valle, Palmer, Thompson, McKay, Büchler.
Statistical analysis: Stocken, Cunningham.
Obtained funding: Neoptolemos, Stocken, Ghaneh, Cunningham, Moore, Gallinger, Lerch, Büchler.
Administrative, technical, or material support: Neoptolemos, Ghaneh, Goldstein, Moore, Izbicki, Lerch, Dervenis, Smith, Valle, Buckels, McKay, Rawcliffe.
Study supervision: Neoptolemos, Bassi, Ghaneh, Padbury, Izbicki, Friess, Dervenis, Oláh, Butturini, Smith, Palmer, Thompson, Büchler.
Ms Rawcliffe was the trial coordinator responsible for central administration ensuring ethical standards for collection and verification of data. The results were interpreted by the ESPAC working party (all of the above). Drs Neoptolemos, Ghaneh, and Stocken prepared the initial draft and were responsible for collating changes proposed by the aforementioned into the final paper before final approval by all participants in the European Study Group for Pancreatic Cancer.
Financial Disclosures: None reported.
Funding/Support: This study was supported by Cancer Research UK; National Cancer Institute of Canada, Canadian Cancer Society; Fonds de Recherche de la Société Nationale Française de Gastroentérologie; Fondazioone Italiana Malattie del Pancreas; Health and Medical Research Council of Australia, Cancer Councils of New South Wales, Queensland, Victoria, and South Australia. Dr Cunningham's work is funded in part by the National Institute for Health Research Biomedical Research Centre at the Royal Marsden Hospital.
Role of the Sponsors: None of the sponsors or funders had any role in the design and conduct of the study; the collection, management, analysis, and interpretation of the data; or the preparation, review, or approval of the manuscript.
The Full List of ESPAC Specialists Who Contributed to the Treatment of Patients in the ESPAC-3 Trial is presented in the eAppendix.
Independent Data and Safety Monitoring Committee: R. P. Ahern, MSc (Institute for Cancer Research, London, United Kingdom), R. C. G. Russell, MD (Middlesex Hospital, London, United Kingdom), P. Clarke, MD (Clatterbridge Centre for Clinical Oncology, Wirral, United Kingdom).
This article was corrected online for typographical errors on 9/7/2010.