Author Contributions: Dr Rebbeck had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Domchek, Friebel, Evans, Eeles, Pichert, Rubinstein, Rebbeck.
Acquisition of data: Domchek, Friebel, Singer, Evans, Lynch, Isaacs, Garber, Neuhausen, Matloff, Eeles, Pichert, Van t’veer, Tung, Weitzel, Couch, Rubinstein, Ganz, Daly, Olopade, Tomlinson, Schildkraut, Blum, Rebbeck.
Analysis and interpretation of data: Domchek, Friebel, Singer, Eeles, Pichert, Tung, Weitzel, Rubinstein, Blum, Rebbeck.
Drafting of the manuscript: Domchek, Friebel, Evans, Lynch, Pichert, Rebbeck.
Critical revision of the manuscript for important intellectual content: Domchek, Friebel, Singer, Evans, Isaacs, Garber, Neuhausen, Matloff, Eeles, Pichert, Van t’veer, Tung, Weitzel, Couch, Rubinstein, Ganz, Daly, Olopade, Tomlinson, Schildkraut, Blum, Rebbeck.
Statistical analysis: Friebel, Pichert, Rubinstein, Rebbeck.
Obtained funding: Singer, Lynch, Isaacs, Neuhausen, Pichert, Olopade, Rebbeck.
Administrative, technical, or material support: Domchek, Friebel, Singer, Evans, Neuhausen, Matloff, Eeles, Pichert, Van t’veer, Tung, Weitzel, Couch, Ganz, Daly, Tomlinson, Schildkraut, Blum, Rebbeck.
Study supervision: Domchek, Lynch, Eeles, Pichert, Weitzel, Rebbeck.
Financial Disclosures: None reported.
Funding/Support: This study was supported by grants R01-CA83855 and R01-CA102776 from the Public Health Service (awarded to Dr Rebbeck); funding from the University of Pennsylvania Cancer Center (awarded to Dr Rebbeck); grant HHSN21620074400C from the Cancer Genetics Network (awarded to Drs Domchek and Isaacs); funding from the Marjorie Cohen Research Fund (awarded to Dr Domchek); SPORE grant BC P50 CA-089393 from the Dana-Farber/Harvard Cancer Center (awarded to Dr Garber); grants DAMD-17-96-I-6088 (awarded to Andrew K. Godwin), DAMD-17-94-J-4340 and DAMD-17-97-I-7112 (awarded to Dr Lynch), and DAMD-17-03-1-0619 (awarded to Dr Domchek) from the US Department of Defense; grant P30-CA51008-15 (awarded to Georgetown University); funding from the Utah Cancer registry (which was funded by Public Health Service grant NO1-CN-6700) and the Utah State Department of Health; Nebraska State Cancer and Smoking-Related Diseases Research Program grants LB595 (awarded to Dr Lynch) and P30-CA-16042 (awarded to Dr Ganz); Cancer Research UK grant C5047/A7357 (awarded to Dr Eeles); and National Cancer Institute grant P30 CA51008-12 (awarded to Dr Isaacs). Dr Olopade receives funding as the Doris Duke Distinguished Clinical Scientist. Dr Eeles received funding from the National Institute for Health Research (awarded to the Biomedical Research Centre at the Institute of Cancer Research and the Royal Marsden NHS Foundation Trust).
Role of the Sponsor: The sponsors had no role in the design and conduct of the study; in the collection, management, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript.
The PROSE Consortium includes the following individuals and centers. The number of participants who were included in the present study appears in the parentheses. Christian Singer, University of Vienna, Austria (n = 283); Nadine Tung, Beth Israel, Boston, Massachusetts (n = 119); Joanne L. Blum, Becky Althaus, Gabrielle Ethington, and Estelle Brothers, Baylor-Charles A. Sammons Cancer Center (n = 13); Jeffrey Weitzel, City of Hope, Duarte, California (n = 98); Carrie Snyder, Henry T. Lynch, and Patrice Watson, Creighton University, Omaha, Nebraska (n = 348); Katherine Corso, Kathryn Stoeckert, and Judy E. Garber, Dana-Farber Cancer Institute, Boston, Massachusetts (n = 311); Joellen Schildkraut, Duke University, Durham, North Carolina (n = 19); Wendy S. Rubinstein, Christina Selkirk, and Scott M. Weissman, NorthShore University HealthSystem, Evanston, Illinois (n = 88); Mary B. Daly, Fox Chase Cancer Center, Philadelphia, Pennsylvania (n = 71); Gabriella Pichert, Caroline Langman, and Leena da Silva, Guy's Hospital and St Thomas Foundation Trust, London, England (n = 123); Camille Jasper and Claudine Isaacs, Georgetown University, Washington, DC (n = 315); Patricia A. Ganz and Joyce L. Seldon, University of California, Los Angeles (n = 79); Fergus Couch, Mayo Clinic College of Medicine, Rochester, Minnesota (n = 96); Marc van Beurden and Laura Van t’veer, Netherlands Cancer Institute, Amsterdam, the Netherlands (n = 121); Rosalind Eeles, Elizabeth Bancroft, Elizabeth Page, Lucia D’Mello, Susan Shanley, Audrey Ardern-Jones, Elena Castro, Anita Mitra, Kelly Kohut, and Jennifer Wiggins (Carrier Clinic Collaborators), Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, England (n = 111); Gareth Evans and Andrew Shenton, St Mary's Hospital, Manchester, England (n = 301); Gail Tomlinson, University of Texas-Southwestern, Dallas (n = 38); Shelly Cummings and Olufunmilayo Olopade, University of Chicago, Chicago, Illinois (n = 53); Susan Domchek, Tara M. Friebel, Timothy Rebbeck, Jill Stopfer, Jacquelyn Powers, and Katherine Nathanson, University of Pennsylvania, Philadelphia (n = 296); Susan Neuhausen and Linda Steele, University of Utah, Salt Lake City, and University of California, Irvine (n = 230); Steven A. Narod, Women's College Hospital, Toronto, Ontario, Canada (n = 54); and Ellen T. Matloff and Karina L. Brierly, Yale University, New Haven, Connecticut (n = 127).
Disclaimer: Dr Olopade, a member of JAMA ’s Journal Oversight Committee, did not have any input in the decision to accept the manuscript for publication.
Additional Contributions: This article is dedicated to the late Andrew Shenton, who contributed significantly to this research.