Significant comparative effectiveness research (CER) efforts should be dedicated to understanding the effectiveness of investments across broad determinants of health instead of focusing primarily within the health care domain alone. For instance, the obesity epidemic poses a threat to health outcomes, and costs related to obesity unquestionably arise from a combination of determinants, including medical care; health behaviors; social, economic, and cultural factors; characteristics of the physical and built environment; and genetics. However, limited evidence exists to guide public and private policy makers regarding investments across these determinants. Can CER be used to address such important questions?
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