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Letters | July 28, 2010

Adding Noninsulin Antidiabetic Drugs to Metformin Therapy for Type 2 Diabetes

Helena W. Rodbard, MD; Paul S. Jellinger, MD

JAMA. 2010;304(4):405-407. doi:10.1001/jama.2010.1021.

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To the Editor: Dr Phung and colleagues¹ presented a meta-analysis of the effectiveness of several classes of antidiabetic agents used in combination with metformin, examining the effects on glycemic control, body weight, and hypoglycemia. Sulfonylureas and thiazolidinediones are associated with significant weight gain; sulfonylureas and glinides are associated with increased risk of hypoglycemia. In contrast, DPP-4 inhibitors and GLP-1 agonists are not associated with increased hypoglycemia, and GLP-1 agonists can be associated with significant weight loss. Despite this evidence, the authors advocated use of sulfonylureas because of their lower cost and cautioned against use of DPP-4 inhibitors and GLP-1 agonists in view of what they regard as a smaller evidence base.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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July 28, 2010

Adding Noninsulin Antidiabetic Drugs to Metformin Therapy for Type 2 Diabetes

Dario Giugliano, MD, PhD; Katherine Esposito, MD, PhD

JAMA. 2010;304(4):405-407. doi:10.1001/jama.2010.1020.

July 28, 2010

Adding Noninsulin Antidiabetic Drugs to Metformin Therapy for Type 2 Diabetes—Reply

Craig I. Coleman, PharmD; Olivia J. Phung, PharmD; Jennifer M. Scholle, PharmD

JAMA. 2010;304(4):405-407. doi:10.1001/jama.2010.1022.

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Rodbard HW, Jellinger PS. Adding Noninsulin Antidiabetic Drugs to Metformin Therapy for Type 2 Diabetes. JAMA. 2010;304(4):405-407. doi:10.1001/jama.2010.1021.

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