0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Health Agencies Update |

Trapping Malaria

Bridget M. Kuehn
JAMA. 2010;304(4):398. doi:10.1001/jama.2010.971.
Text Size: A A A
Published online

Extract

Scientists studying how the malaria parasite Plasmodium falciparum multiplies and escapes from an infected blood cell and spreads throughout the body have discovered a potential way to stop the process, according to a recent study published by scientists from the Eunice Kennedy Shriver National Institute of Child Health and Human Development and the National Institute of Diabetes and Digestive and Kidney Diseases.

By studying the parasites multiplying in sickle cells, which are more resistant than typical cells to rupture, the scientists had more time to observe the steps in the process (Glushakova S et al. Curr Biol. 2010;20[12]:1117-1121). They found that prior to the rupture of the blood cell, the vacuole containing the multiplying parasites swells while the erythrocyte shrinks, and that the blood cell membrane becomes porous just before it ruptures. Moreover, they found that sealing the membrane with the compound poloxamine prevents rupture, suggesting a potential strategy for experimental malaria therapies.

Topics

malaria

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
PubMed Articles
Jobs
JAMAevidence.com

The Rational Clinical Examination
Make the Diagnosis: Malaria

The Rational Clinical Examination
Original Article: Does This Patient Have Malaria?

brightcove.createExperiences();