Author Contributions: Dr Cooper, Ms Metch, and Dr Baden had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Cooper, Metch, Coombs, Baden.
Acquisition of data: Dragavon, Coombs, Baden.
Analysis and interpretation of data: Cooper, Metch, Coombs, Baden.
Drafting of the manuscript: Cooper, Metch, Coombs, Baden.
Critical revision of the manuscript for important intellectual content: Cooper, Metch, Dragavon, Coombs, Baden.
Statistical analysis: Cooper, Metch, Baden.
Obtained funding: Baden.
Administrative, technical, or material support: Cooper, Dragavon, Coombs, Baden.
Study supervision: Cooper, Baden.
Financial Disclosures: None reported.
Funding/Support: This work was funded by NIAID grants U01 AI046747, AI068614, AI46725, AI068618, AI046703, AI068635, and AI069412 and by the University of Washington Center for AIDS Research grant AI27757.
Role of the Sponsors: The funders had no role in the design and conduct of the study; the collection, analysis, and interpretation of the data; or the preparation, review, or approval of the manuscript.
National Institute of Allergy and Infectious Diseases (NIAID) HIV Vaccine Trials Network (HVTN) Vaccine-Induced Seropositivity (VISP) Task Force: Mary Allen, Sarah Alexander, Constance Ducar, Alan Fix, Renee Holt, Shelly Karuna, Genevieve Meyer, Miko Robertson, Kyle Rybczyk, Richard Shikiar, Steve Wakefield, Margaret Wecker.
Previous Presentation: Presented in part at AIDS Vaccine 2008; October 14, 2008; Cape Town, South Africa.
Additional Contributions: We thank Haynes “Chip” Sheppard, PhD, California Department of Health Services Viral and Rickettsial Disease Laboratory, for the pre-2006 HIV testing for the end-of-study algorithms and HIV testing data. Dr Sheppard was previously under contract with the NIAID HVTN.