Author Contributions: Dr Grinspoon had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Lee, Grinspoon.
Acquisition of data: Lo, You, Liebau, Grinspoon.
Analysis and interpretation of data: Lo, You, Lee, Grinspoon.
Drafting of the manuscript: Grinspoon.
Critical revision of the manuscript for important intellectual content: Lo, You, Liebau, Lee, Grinspoon.
Statistical analysis: Lo, Lee, Grinspoon.
Obtained funding: Grinspoon.
Administrative, technical, or material support: Lo, You, Liebau, Grinspoon.
Study supervision: Grinspoon.
Financial Disclosures: Dr Grinspoon reported having served as a consultant for EMD Serono, Theratechnologies, Stratum Medical, and Hoffman LaRoche, and having received research support from Theratechnologies, EMD Serono, Bristol-Myers Squibb, and GlaxoSmithKline. Dr Grinspoon also reported having provided expert testimony before a Food and Drug Administration advisory panel as the principal investigator of a study of growth hormone releasing hormone. Ms You reported having received salary support from Genentech for an unrelated project. No other disclosures were reported.
Funding/Support: The study was funded by grants R01 DK63639 (S.G.), K23 HL092792 (J. Lo), M01 RR01066, and 1 UL1 RR025758 from the National Institutes of Health; by the Harvard Clinical and Translational Science Center; and by the National Center for Research Resources. EMD Serono provided growth hormone and placebo but did not provide funding for the study.
Role of the Sponsor: The funding organizations approved the study and its design but had no role in the conduct of the study; in the collection, management, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript. EMD Serono had no role in the study design, conduct, or analysis or decisions about manuscript submission. EMD Serono reviewed an early draft of the manuscript as per the Product Donation Agreement but did not review the final version of the manuscript and did not make any decisions regarding content.
Disclaimer: The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Center for Research Resources or the National Institutes of Health.
Additional Contributions: Jeffrey Wei, BA, Massachusetts General Hospital Program in Nutritional Metabolism, helped with data collection and analysis. Mr Wei did not receive compensation for his role in the study.