Despite modest prevention successes, 2.7 million new human immunodeficiency virus (HIV) infections occurred worldwide in 2008 and there were at least 2 million HIV-associated deaths.1 Nearly 3 million persons in sub-Saharan Africa are now taking antiretroviral therapy (ART)1—an impressive accomplishment. The urgency of sustaining treatment for these patients, and reaching more than 15 million persons with unmet care and treatment needs,1 underscores the need to reduce HIV incidence. HIV testing and counseling among serodiscordant couples has been associated with reduced transmission, increased condom use, and reduction in sex acts with outside partners2,3 as well as increased ART uptake among pregnant women in antenatal clinics.4 Reframing HIV prevention using a couple-centered approach could help enhance current prevention efforts.
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