0
Letters |

Bias and Trials Stopped Early for Benefit—Reply

Gordon H. Guyatt, MD, MSc; Dirk Bassler, MD, MSc; Victor M. Montori, MD, MSc
JAMA. 2010;304(2):156-159. doi:10.1001/jama.2010.934.
Text Size: A A A
Published online

Extract

In Reply: Authors of all 4 letters acknowledge that truncated randomized controlled trials (tRCTs) overestimate treatment effects; controversy remains as to by how much and what should be done about it. A pivotal issue is what real-world data should be used to quantify overestimates. Ideally, trials with fixed sample size and no provision for early stopping would be available. Such trials are rare and typically not identifiable through reading their methods. Feasible alternatives are therefore all trials not stopped early (our primary comparison, with which Dr Berry and colleagues and Dr Goodman and colleagues disagree, describing it as a logical error) or all trials including tRCTs (our secondary comparison).

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
/>
First page PDF preview

Figures

Tables

References

July 14, 2010
Scott M. Berry, PhD; Bradley P. Carlin, PhD; Jason Connor, PhD
JAMA. 2010;304(2):156-159. doi:10.1001/jama.2010.930.
July 14, 2010
Steven Goodman, MD, MHS, PhD; Donald Berry, PhD; Janet Wittes, PhD
JAMA. 2010;304(2):156-159. doi:10.1001/jama.2010.931.
July 14, 2010
Edward L. Korn, PhD; Boris Freidlin, PhD; Margaret Mooney, MD
JAMA. 2010;304(2):156-159. doi:10.1001/jama.2010.932.
July 14, 2010
Susan S. Ellenberg, PhD; David L. DeMets, PhD; Thomas R. Fleming, PhD
JAMA. 2010;304(2):156-159. doi:10.1001/jama.2010.933.
CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Web of Science® Times Cited: 9

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Topics
Jobs
JAMAevidence.com

The Rational Clinical Examination
Make the Diagnosis: Cancer, Family History

The Rational Clinical Examination
Original Article: Does This Patient Have a Family History of Cancer?

brightcove.createExperiences();