Author Contributions: Dr Biggs had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Luchsinger, Biggs, Siscovick, Mukamal, Newman, Carnethon.
Acquisition of data: Siscovick, Newman.
Analysis and interpretation of data: Biggs, Mukamal, Ix, Luchsinger, Newman, de Boer, Newman, Siscovick, Strotmeyer, Mozaffarian.
Drafting of manuscript: Biggs.
Critical revision of manuscript for important intellectual content: Biggs, Mukamal, Ix, Carnethon, Newman, de Boer, Newman, Siscovick, Luchsinger, Strotmeyer, Mozaffarian.
Statistical analysis: Biggs.
Obtained funding: Siscovick, Newman, Mukamal, Ix.
Administrative, technical, or material support: Newman.
Study supervision: Siscovick, Newman, Mukamal.
Financial Disclosures: None reported.
Funding/Support: The research reported in this article was supported by contract numbers N01-HC-85079 through N01-HC-85086, N01-HC-35129, N01-HC-15103, N01-HC-55222, N01-HC-75150, N01-HC-45133, and grant numbers U01 HL080295, R01 HL-075366, and R01 HL-094555 from the National Heart, Lung, and Blood Institute; R01 AG-023629, R01 AG-15928, R01 AG-20098, and AG-027058 from the National Institute on Aging; the University of Pittsburgh Claude. D. Pepper Older Americans Independence Center P30-AG-024827, with additional contribution from the National Institute of Neurological Disorders and Stroke.
Role of the Sponsors: The study sponsors had no role in the design and conduct of this study; the collection, management, analysis, and interpretation of the data; or the preparation, review, or approval of the manuscript.
Cardiovascular Health Study Investigators and Institutions: A full list of principal Cardiovascular Health Study investigators and institutions can be found at http://www.chs-nhlbi.org/pi.htm.