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Influenza Vaccination of Children and Infection Rates in the Community

Parker A. Small, MD; J. Glenn Morris, MD, MPH&TM
JAMA. 2010;303(23):2355-2356. doi:10.1001/jama.2010.779.
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To the Editor: The randomized study by Dr Loeb and colleagues1 of communities receiving either inactivated influenza vaccine or hepatitis A vaccine supports school-based influenza immunization and adds credence to a nationwide Japanese study that concluded that 1 life was saved for every 420 children immunized against influenza.2 The study by Loeb et al showed protection of community members against clinical illness, confirmed by real-time reverse transcriptase–polymerase chain reaction assay, but failed to show protection against infection as determined by hemagglutination inhibition titers. The authors speculated that “[o]ne possible explanation for the lack of significant differences in serologic outcomes is that the influenza vaccination may have attenuated infection that . . . rendered it subclinical but without preventing infection.”


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June 16, 2010
Mark Loeb, MD, MSc; Margaret Russell, MD, PhD; David J. D. Earn, PhD
JAMA. 2010;303(23):2355-2356. doi:10.1001/jama.2010.780.
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