In Reply: In response to Drs Rusthoven and Pugh, several prospective series have shown a rather low rate of regional recurrence after SBRT, perhaps different than would be predicted based on larger surgical series defining pathological tumor involvement within nodes of initially clinically staged patients.1,2 A number of possible explanations have been offered, including a theory regarding immune stimulation after tumor ablative SBRT as suggested by Rusthoven and Pugh.3 Counter to this argument, however, is the higher rate of distant dissemination observed in our study. If the primed immune system is capable of eliminating micrometastases in the regional lymphatics, it is not clear why it would be less effective in distant organs.
Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more
Subscribe for full-text access to content from 1998 forward and a host of useful features
Activate your current subscription (AMA members and current subscribers)
Purchase Online Access to this article for 24 hours
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 2
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
and access these and other features:
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.