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Letters | June 2, 2010

Aspirin for Prevention of Cardiovascular Events in Individuals With Low Ankle Brachial Index—Reply

Jeffrey S. Berger, MD, MS

JAMA. 2010;303(21):2136-2137. doi:10.1001/jama.2010.699.

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In Reply: In the Aspirin for Asymptomatic Atherosclerosis trial,¹ aspirin was not demonstrated to be effective in decreasing cardiovascular events in participants free of CVD but with a screening-detected ABI at 0.95 or lower. Similarly, the Prevention of Progression of Arterial Disease and Diabetes (POPADAD) trial found no benefit of aspirin in diabetic patients free of CVD with a screening ABI at 0.99 or lower.² In both of these trials, a screening ABI used for study inclusion was not demonstrated to identify a population that would benefit from aspirin therapy. To help determine the appropriate use of ABI (or any screening diagnostic test), a better understanding of whether the test will lead to a change in management is needed.

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June 2, 2010

Aspirin for Prevention of Cardiovascular Events in Individuals With Low Ankle Brachial Index

Joshua A. Beckman, MD

JAMA. 2010;303(21):2136-2137. doi:10.1001/jama.2010.697.

June 2, 2010

Aspirin for Prevention of Cardiovascular Events in Individuals With Low Ankle Brachial Index—Reply

F. Gerald R. Fowkes, PhD, FRCPE; Jacqueline F. Price, MD; Gordon D. Murray, PhD, FRSE

JAMA. 2010;303(21):2136-2137. doi:10.1001/jama.2010.698.

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Berger JS. Aspirin for Prevention of Cardiovascular Events in Individuals With Low Ankle Brachial Index—Reply. JAMA. 2010;303(21):2136-2137. doi:10.1001/jama.2010.699.

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