Author Contributions: Dr Boutron had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Boutron, Dutton, Ravaud, Altman.
Acquisition of data: Boutron, Dutton.
Analysis and interpretation of data: Boutron, Dutton, Ravaud, Altman.
Drafting of the manuscript: Boutron.
Critical revision of the manuscript for important intellectual content: Dutton, Ravaud, Altman.
Statistical analysis: Boutron.
Financial Disclosures: None reported.
Funding/Support: Dr Boutron was supported by a grant from the Societe Francaise de Rhumatologie (SFR) and that Lavoisier Program (Ministère des Affaires étrangères et européennes).
Role of the Sponsors: The SFR and the Lavoisier Program (Ministère des Affaires étrangères et européennes) had no role in the design and conduct of the study; the collection, management, analysis, and interpretation of the data; or the preparation, review, or approval of the manuscript.
Additional Contributions: We are very grateful to Ly-Mee Yu, Msc (Center for Statistics in Medicine, University of Oxford, Oxford, United Kingdom), for her important work in developing the database of the representative reports of randomized controlled trials indexed in PubMed. Ms Yu received no compensation for her contributions.