Author Contributions: Dr Paoletti had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Drs Paoletti and Oba contributed equally to this work.
Study concept and design: Paoletti, Oba, Burzykowski, Michiels, Ohashi, Pignon, Rougier, Sakamoto, Sasako, Buyse.
Acquisition of data: Paoletti, Oba, Ohashi, Sakamoto, Sargent, Sasako, Van Cutsem, Buyse.
Analysis and interpretation of data: Paoletti, Oba, Burzykowski, Michiels, Pignon, Rougier, Sargent, Van Cutsem, Buyse.
Drafting of the manuscript: Paoletti, Oba, Burzykowski, Sasako, Buyse.
Critical revision of the manuscript for important intellectual content: Paoletti, Oba, Burzykowski, Michiels, Ohashi, Pignon, Rougier, Sakamoto, Sargent, Van Cutsem, Buyse.
Statistical analysis: Paoletti, Oba, Burzykowski, Michiels, Pignon, Sargent, Buyse.
Obtained funding: Oba, Ohashi.
Administrative, technical, or material support: Paoletti, Oba, Sakamoto, Sargent.
Study supervision: Paoletti, Ohashi, Rougier, Sasako, Van Cutsem, Buyse.
Financial Disclosures: None reported.
Funding/Support: This project was partially funded by the Japan Clinical Research Support Unit (J-CRSU), the Epidemiological and Clinical Research Information Network (ECRIN), and the Institut National du Cancer (INCa), France.
Role of the Sponsor: The project was initiated under the auspice of the INCa, who served as a sponsor. The INCa did not participate in the design of the study. It participated in the conduct of the study by centralizing all the databases and by providing administrative and data management support. The sponsor did not participate in the analysis and interpretation of the data, which were solely the responsibility of the writing committee. The sponsor had no role in the preparation, review, or approval of the manuscript.
The GASTRIC Investigators:Secretariat: Marc Buyse, Stefan Michiels, Koji Oba, Xavier Paoletti, Philippe Rougier, Seiichiro Yamamoto, Kenichi Yoshimura; Steering Committee: Yung-Jue Bang (Seoul National University College of Medicine, Seoul, Korea); Harry Bleiberg (Brussels, Belgium); Tomasz Burzykowski (Hasselt University, Diepenbeek, Belgium); Marc Buyse (International Drug Development Institute, Louvain-la-Neuve, Belgium); Catherine Delbaldo (University Hospital Henri Mondore, AP-HP, Créteil, France); Stefan Michiels (Institut Gustave-Roussy, Villejuif, France); Satoshi Morita (Yokohama City University, Kanagawa, Japan); Yasuo Ohashi (University of Tokyo, Tokyo, Japan); Xavier Paoletti (Institut National du Cancer, Boulogne, France); Jean-Pierre Pignon (Institut Gustave-Roussy); Carmelo Pozzo (Catholic University of the Sacred Heart, Rome, Italia); Philippe Rougier (University Hospital Ambroise Paré [AP-HP], Boulogne); Junichi Sakamoto (Nagoya University, Aichi, Japan); Daniel Sargent (Mayo Clinic, Rochester, Minnesota); Mitsuru Sasako (Hyogo College of Medicine, Hyogo, Japan); Eric Van Cutsem (Digestive Oncology Unit, University Hospital Gasthuisberf, Leuven, Belgium); Collaborators Who Supplied Individual Patient Data: Steven Alberts (Mayo Clinic); Emilio Bajetta (Department of Medical Oncology, IRCCS Fondazione Istituto Nazionale dei Tumori, Milan, Italy); Jacqueline Benedetti (SWOG Statistical Center, Seattle, Washington); Franck Bonnetain, FFCD (Dijon, France); Olivier Bouche (Department of Gastro-Intestinal Oncology, University Hospital Robert Debré, Reims, France); R. Charles Coombes (Medical Oncology Unit, Charing Cross Hospital, London, United Kingdom); Maria Di Bartolomeo (Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori); Juan J. Grau (Department of Oncology, Institut Clinic de Malalties Hemato-Oncologiques of Hospital Clinic, University of Barcelona, Barcelona, Spain); Juan C. Garcia-Valdecasas (Department of Oncology, Institut Clinic de Malalties Hemato-Oncologiques of Hospital Clinic, University of Barcelona); Josep Fuster (Department of Oncology, Institut Clinic de Malalties Hemato-Oncologiques of Hospital Clinic, University of Barcelona); James E. Krook (Mayo Clinic); Florian Lordick (National Center for Tumor Diseases, Department of Medical Oncology, University of Heidelberg, Heidelberg, Germany); Mario Lise (Department of Oncological and Surgical Sciences, University of Padua, Padua, Italy); John S. Macdonald (St Vincent's Cancer Center, New York, New York); Pierre Michel (Department of Gastro-Intestinal Oncology, Charles-Nicolle University Hospital, Rouen, France); Toshifusa Nakajima (Cancer Institute Hospital, Tokyo, Japan); Atsushi Nashimoto (Niigata Cancer Center Hospital, Niigata, Japan); Garth D. Nelson (Mayo Clinic); Donato Nitti (Department of Oncological and Surgical Sciences, University of Padua); Tadeusz Popiela (Department of Surgery, Jagiellonian University Medical College, Krakow, Poland); Philippe Rougier (University Hospital Ambroise Paré); Nicolas Tsavaris (Laiko University Hospital, Athens, Greece).
Disclaimer: The conclusions may not reflect the views of the INCa.
Additional Contributions: The GASTRIC Group thanks all patients who took part in the trials and contributed to this research. The meta-analysis would not have been possible without their participation or without active participation of the collaborating institutions that provided their trial data (ECOG, EORTC, FFCD, GITSG, ICCG, ITMO, JCOG, NCCTG, SWOG, Hospital Clinic Villarroel of Barcelona, Metaxa Cancer Hospital, Jagiellonian of Pireus University, Medical College of Krakow). We thank the EMMES Corporation, Rockville, Maryland, for extracting the GITSG data. Caroline Tournoux-Facon, MD, and Elise Seringe, MD (INCa, France), helped in the project management, and Frédéric Agnola (INCa, France) helped in data management. They did not receive compensation. We are indebted to Sanofi-Aventis for funding 3 investigator meetings.