Author Contributions: Dr Hernandez had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Hernandez, Greiner, Fonarow, Heidenreich, Yancy, Curtis.
Acquisition of data: Hernandez, Greiner, Fonarow, Peterson.
Analysis and interpretation of data: Hernandez, Greiner, Fonarow, Hammill, Heidenreich, Curtis.
Drafting of the manuscript: Hernandez, Greiner, Fonarow.
Critical revision of the manuscript for important intellectual content: Greiner, Fonarow, Hammill,
Heidenreich, Yancy, Peterson, Curtis.
Statistical analysis: Greiner, Hammill.
Obtained funding: Hernandez, Fonarow.
Administrative, technical, or material support: Fonarow, Yancy, Curtis.
Study supervision: Hernandez, Fonarow, Peterson.
Financial Disclosures: Dr Hernandez reported receiving research support from Johnson & Johnson, Medtronic, and Merck & Co; serving on the speakers' bureau for Novartis; and receiving honoraria from AstraZeneca and Medtronic. Dr Fonarow reported receiving research grants or other research support from GlaxoSmithKline, Pfizer, and the National Institutes of Health; receiving honoraria from Amgen, AstraZeneca, Boston Scientific/Guidant, GlaxoSmithKline, Medtronic, Merck, Novartis, Pfizer, Schering Plough, and St Jude Medical; serving as a consultant to Boston Scientific/Guidant, GlaxoSmithKline, Medtronic, Merck, Novartis, Pfizer, Scios, and St Jude Medical; and serving on the American Heart Association's Get With the Guidelines Steering Committee. He holds the Eliot Corday Chair of Cardiovascular Medicine and is also supported by the Ahmanson Foundation (Los Angeles, California). Dr Yancy terminated all financial relationships in June 2008. Before 2008, Dr Yancy reported receiving research grants from Cardiodynamics, GlaxoSmithKline, Scios, Medtronic, and NitroMed; serving as a consultant to or on the speakers' bureaus of AstraZeneca, Cardiodynamics, GlaxoSmithKline, Medtronic, NitroMed, Novartis, and Scios; serving on advisory boards of CHF Solutions; and receiving honoraria from AstraZeneca, Cardiodynamics, GlaxoSmithKline, Medtronic, Novartis, and Scios. Dr Peterson reported receiving research support from Bristol-Myers Squibb, Sanofi-Aventis, Merck Schering, and Eli Lilly; and serving as the principal investigator of the analytic center for the American Heart Association Get With the Guidelines Program. Dr Curtis reported receiving research support from Johnson & Johnson and Medtronic. Drs Hernandez, Peterson, and Curtis have made available online detailed listings of financial disclosures (http://www.dcri.duke.edu/research/coi.jsp).
Funding/Support: Get With the Guidelines-Heart Failure is a program of the American Heart Association and is supported in part by an unrestricted educational grant from GlaxoSmithKline and Medtronic. OPTIMIZE-HF was supported by GlaxoSmithKline. This study was supported by American Heart Association Pharmaceutical Roundtable Outcomes Center grant 087512N. Dr Hernandez was supported by American Heart Association Pharmaceutical Roundtable grant 0675060N. Drs Peterson and Curtis were supported by grant U18HS016964 from the Agency for Healthcare Research and Quality.
Role of the Sponsor: The American Heart Association, GlaxoSmithKline, and Medtronic had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; or preparation of the manuscript. Representatives from the American Heart Association reviewed and approved a draft of the manuscript.
Disclaimer: Dr Peterson, a contributing editor for JAMA, was not involved in the editorial review of or the decision to publish this article.
Additional Contributions: We thank Damon M. Seils, MA, Duke University, for editorial assistance and manuscript preparation. Mr Seils did not receive compensation for his assistance apart from his employment at the institution where the study was conducted.