Author Contributions: Dr Polonsky had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Polonsky, McClelland, Greenland.
Acquisition of data: McClelland, Bild, Burke, Guerci, Greenland.
Analysis and interpretation of data: Polonsky, McClelland, Jorgensen, Bild, Burke, Guerci, Greenland.
Drafting of the manuscript: Polonsky, Greenland.
Critical revision of the manuscript for important intellectual content: McClelland, Jorgensen, Bild, Burke, Guerci.
Statistical analysis: McClelland, Jorgensen.
Obtained funding: Bild, Burke, Guerci, Greenland.
Administrative, technical or material support: Polonsky, McClelland, Jorgensen, Bild, Burke, Guerci, Greenland.
Study supervision: McClelland, Bild, Burke, Guerci, Greenland.
Financial Disclosures: Dr Guerci reports that he has received grant support from Pfizer. Dr Greenland reports that he has served as a consultant to Pfizer and GE/Toshiba. No other disclosures were reported.
Funding/Support: MESA was supported by contracts N01-HC-95159 through N01-HC-95169 from the National Heart, Lung, and Blood Institute (NHLBI). Dr Polonsky is supported by an NHLBI training grant in cardiovascular epidemiology and prevention (grant 5T32HL069771). Dr Greenland is supported by a grant from the National Center for Research Resources (grant number 1UL1RR025741).
Role of the Sponsors: The NHLBI participated in the design and conduct of MESA. A member of the NHLBI staff served as a coauthor and had input into the collection, management, analysis, and interpretation of the data and in preparation of the manuscript, as did the other coauthors. Although additional members of the NHLBI staff were able to view the manuscript prior to submission, they did not participate in the decision to submit the manuscript or approve it prior to publication. The National Center for Research Resources had no role in the design and conduct of the study, in the collection, analysis, and interpretation of the data, or in the preparation, review, or approval of the manuscript.
Additional Information: A full list of participating MESA investigators and institutions can be found at http://www.mesa-nhlbi.org.
Additional Contributions: We thank the other investigators, the staff, and the participants of MESA for their valuable contributions.