Author Contributions: Dr A. Gratwohl had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: A. Gratwohl, Bouzas, Yoshimi, Szer, Niederwieser, Horowitz, Kodera.
Acquisition of data: Baldomero, Aljurf, Pasquini, Bouzas, Yoshimi, Lipton, Horowitz, Kodera.
Analysis and interpretation of data: A. Gratwohl, Baldomero, Bouzas, Yoshimi, Szer, Schwendener, M. Gratwohl, Frauendorfer, Niederwieser, Horowitz, Kodera.
Drafting of the manuscript: A. Gratwohl, Pasquini, Bouzas, Yoshimi, Szer, Niederwieser, Kodera.
Critical revision of the manuscript for important intellectual content: Baldomero, Aljurf, Bouzas, Yoshimi, Szer, Lipton, Schwendener, M. Gratwohl, Frauendorfer, Niederwieser, Horowitz, Kodera.
Statistical analysis: Pasquini, Bouzas, Yoshimi, Schwendener, M. Gratwohl, Frauendorfer, Kodera.
Obtained funding: A. Gratwohl, Pasquini, Bouzas, Yoshimi, Horowitz, Kodera.
Administrative, technical, or material support: Baldomero, Aljurf, Pasquini, Bouzas, Yoshimi, Niederwieser, Kodera.
Study supervision: A. Gratwohl, Pasquini, Bouzas, Yoshimi, Lipton, Kodera.
Financial Disclosures: None reported.
Funding/Support: This work was supported in part by grant LSH-2002-2.2.0-3 from the European Leukaemia Net, by grant 3200B0-118176 from the Swiss National Research Foundation, the Swiss Cancer League, the Regional Cancer League, and the Horton Foundation. The Center for International Blood and Marrow Transplantation is supported by public health service grant/cooperative agreement U24-CA76518 from the National Cancer Institute, the National Heart, Lung, and Blood Institute, and the National Institute of Allergy and Infectious Diseases; by grant/cooperative agreement 5U01HL069294 from the National Heart, Lung, and Blood Institute and the National Cancer Institute; by contract HHSH234200637015C with the Health Resources and Services Administration; by grants N00014-06-1-0704 and N00014-08-1-0058 from the Office of Naval Research; and by grants from AABB, Aetna, the American Society for Blood and Marrow Transplantation, Amgen Inc, an anonymous donation to the Medical College of Wisconsin, Astellas Pharma US Inc, Baxter International Inc, Bayer HealthCare Pharmaceuticals, Be the Match Foundation, Biogen IDEC, BioMarin Pharmaceutical Inc, Biovitrum AB, Blood Center of Wisconsin, Blue Cross and Blue Shield Association, Bone Marrow Foundation, Canadian Blood and Marrow Transplant Group, CaridianBCT, Celgene Corporation, CellGenix GmbH, Centers for Disease Control and Prevention, Children's Leukemia Research Association, ClinImmune Labs, CTI Clinical Trial and Consulting Services, Cubist Pharmaceuticals, Cylex Inc, CytoTherm, DOR BioPharma Inc, Dynal Biotech (an Invitrogen company), Eisai Inc, Enzon Pharmaceuticals Inc, the European Group for Blood and Marrow Transplantation, Gamida Cell Ltd, GE Healthcare, Genentech Inc, Genzyme Corporation, Histogenetics Inc, HKS Medical Information Systems, Hospira Inc, Infectious Diseases Society of America, Kiadis Pharma, Kirin Brewery Co Ltd, the Leukemia & Lymphoma Society, Merck & Company, the Medical College of Wisconsin, MGI Pharma Inc, Michigan Community Blood Centers, Millennium Pharmaceuticals Inc, Miller Pharmacal Group, Milliman USA Inc, Miltenyi Biotec Inc, National Marrow Donor Program, Nature Publishing Group, New York Blood Center, Novartis Oncology, Oncology Nursing Society, Osiris Therapeutics Inc, Otsuka America Pharmaceutical Inc, Pall Life Sciences, Pfizer Inc, Saladax Biomedical Inc, Schering Corporation, Society for Healthcare Epidemiology of America, StemCyte Inc, StemSoft Software Inc, Sysmex America Inc, Teva Pharmaceutical Industries, THERAKOS Inc, Thermogenesis Corporation, Vidacare Corporation, Vion Pharmaceuticals Inc, ViraCor Laboratories, ViroPharma Inc, and Wellpoint Inc. The European Group for Blood and Marrow Transplantation is supported by grants from the corporate members Amgen Europe, ViroPharma Europe, Gilead Sciences UK, Miltenyl Biotec GmbH, Schering-Plough, Celegene International SARL, Genzyme, Fresenius Biotech GmbH, Therakos, Bristol-Myers Squibb, Cephalon, F. Hoffmann-La Roche Ltd, Pierre Fabre Médicament, Alexion Europe, Pfizer, Merck Sharp and Dohme, Chugai Sanofi-Aventis, and Novartis.
Role of the Sponsor: The funding organizations and sponsors of the organizations had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript. Funding support from corporate members was solely for keeping the infrastructure of the organizations. No individual payment was made to any of the persons involved in the study by the sponsors or organizations.
Disclaimer: The views expressed in this article do not reflect the official policy or position of the National Institute of Health, the Department of the Navy, the Department of Defense, or any other agency of the US government.
Additional Contributions: We greatly appreciate the cooperation of all participating teams, countries, and organizations and their staff (see eTable); specifically, the following: the Australian Bone Marrow Transplant Recipient Registry; the Asian Pacific Blood and Marrow Transplant Group (Minako Iida, MD, PhD); Aichi Medical School; the Canadian Blood and Marrow Transplant Group; the Center for International Blood and Marrow Transplantation (Kathy Sobocinski, MS, and Wensheng He, MS); the Medical College of Wisconsin; European Group for Bone Marrow Transplantation coordination offices in Barcelona, Spain, Paris, France, and London, England; the Austrian Registry; the Czech Bone Marrow Transplantation Registry; the French Registry; the German Registry; the Italian Registry; the Dutch Registry; the Spanish Bone Marrow Transplantation Registry; the Swiss Registry; the Turkish Bone Marrow Transplantation Registry; and the British Registry. We also thank Susanna Stöckli (University Hospital Basel) for excellent secretarial assistance.