Author Contributions: Dr Patorno had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Patorno, Bohn, Wahl, Avorn, Patrick, Schneeweiss.
Acquisition of data: Patorno, Bohn, Wahl, Avorn, Schneeweiss.
Analysis and interpretation of data: Patorno, Bohn, Wahl, Liu, Schneeweiss.
Drafting of the manuscript: Patorno, Schneeweiss.
Critical revision of the manuscript for important intellectual content: Patorno, Bohn, Wahl, Avorn, Patrick, Liu, Schneeweiss.
Statistical analysis: Patorno, Bohn, Wahl, Patrick, Liu, Schneeweiss.
Obtained funding: Bohn, Avorn, Schneeweiss.
Administrative, technical, or material support: Bohn, Schneeweiss.
Study supervision: Bohn, Schneeweiss.
Financial Disclosures: Dr Bohn and Mr Wahl reported being employed by HealthCore Inc, a subsidiary of WellPoint, through the study execution. Dr Bohn reported that she has recently left the company and works as an independent consultant. Dr Schneeweiss reported being a paid member of the scientific safety advisory boards of HealthCore Inc and ii4sm; being a paid consultant to HealthCore, World Health Information Science Consultants, and RTI International; and having received an investigator-initiated research grant on the safety of nonsteroidal anti-inflammatory drugs from Pfizer. No other disclosures were reported.
Funding/Support: This study was supported by the HealthCore Fellowship in Pharmacoepidemiology and the Pharmacoepidemiology Research and Training Fund of the Harvard School of Public Health (Dr Patorno).
Role of the Sponsor: HealthCore had no role in the design and conduct of the study; in the analysis and interpretation of the data; or in the preparation, review, or approval of the manuscript.