Author Contributions: Ms Stringhini had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Stringhini, Sabia, Shipley, Singh-Manoux.
Acquisition of data: Brunner, Kivimaki, Singh-Manoux.
Analysis and interpretation of data: Stringhini, Sabia, Shipley, Brunner, Nabi, Kivimaki, Singh-Manoux.
Drafting of the manuscript: Stringhini, Singh-Manoux.
Critical revision of the manuscript for important intellectual content: Stringhini, Sabia, Shipley, Brunner, Nabi, Kivimaki, Singh-Manoux.
Statistical analysis: Stringhini, Sabia, Shipley.
Obtained funding: Singh-Manoux.
Administrative, technical, or material support: Sabia, Shipley, Kivimaki, Singh-Manoux.
Study supervision: Singh-Manoux.
Financial Disclosures: None reported.
Funding/Support: Mr Shipley is supported by the British Heart Foundation. Dr Singh-Manoux is supported by a European Young Investigator Award from the European Science Foundation. The Whitehall II Study has been supported by grants from the British Medical Research Council, the British Heart Foundation, the British Health and Safety Executive, the British Department of Health; grant R01HL036310 from the US National Heart, Lung, and Blood Institute; and grants R01AG013196 and R01AG034454 from the US National Institute on Aging.
Role of Sponsor: The funding organizations had no role in the design and conduct of the study; collection, management, analysis, and interpretation of data; and preparation, review, or approval of the manuscript.
Additional Contributions: We thank all of the participating civil service departments and their welfare, personnel, and establishment officers; the British Occupational Health and Safety Agency; the British Council of Civil Service Unions; all participating civil servants in the Whitehall II study; and all members of the Whitehall II study team. The Whitehall II Study team comprises research scientists, statisticians, study coordinators, nurses, data managers, administrative assistants, and data entry staff, who make the study possible.