Author Contributions: Drs Fowkes and Price as co-first authors had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Fowkes, Price, Sandercock, Lowe, Murray.
Acquisition of data: Stewart.
Analysis and interpretation of data: Fowkes, Price, Butcher, Leng, Pell, Sandercock, Fox, Murray.
Drafting of the manuscript: Fowkes, Price.
Critical revision of the manuscript for important intellectual content: Fowkes, Price, Stewart, Butcher, Leng, Pell, Sandercock, Fox, Lowe, Murray.
Statistical analysis: Butcher, Murray.
Obtained funding: Fowkes, Price, Lowe, Murray.
Administrative, technical, or material support: Stewart, Leng, Pell, Sandercock.
Study supervision: Fowkes, Price, Sandercock, Lowe, Murray.
Financial Disclosures: Drs Fowkes and Price reported that they have received research support from Bayer HealthCare. Drs Fowkes and Sandercock reported that they have received lecture fees and expenses from Bayer HealthCare. Dr Fowkes reported that he has received research support and honoraria from Sanofi-Aventis and Bristol-Myers Squibb. No other authors reported disclosures.
Committees and Other Contributing Groups:Steering Committee: F. G. R. Fowkes (chair), M. Bain, R. Clements, J. Darnborough, I. J. Deary, K. A. A. Fox, G. C. Leng, G. D. O. Lowe, E. Mallinson, G. D. Murray, A. C. H. Pell, J. F. Price, A. Rumley, P. A. G. Sandercock, and J. Wrench. Management Committee: M. Bree, S. Cudmore, A. F. Douglas, M. C. W. Stewart, S. A. Wilson, E. M. Armstrong, F. G. R. Fowkes, G. D. Murray, and J. F. Price. Writing Committee: F. G. R. Fowkes, J. F. Price, M. C. W. Stewart, I. Butcher, G. C. Leng, A. C. H. Pell, P. A. G. Sandercock, K. A. A. Fox, G. D. O. Lowe, and G. D. Murray. Data Monitoring Committee S. M. Cobbe (chair), I. Ford, and C. P. Warlow. Outcome Events Committee: J. Bray, E. Bream, M. Bree, F. G. R. Fowkes, V. Katikireddi, R. Lindley, J. Morling, D. Northridge, J. F. Price, C. A. M. Ritchie, T. Sommerfield, and R. Walton. Data Collection: E. Tolmie, E. C. Graham, J. F. Alexander, H. Lawrie, E. M. Armstrong, I. F. Tierney, S. A. Wilson, P. Ross, F. Reston, D. Willis, E. M. Kerracher, F. J. Neary, F. B. Smith, K. Hepburn, C. D. Rea, H. Mackay, W. A. Smith, C. D. Martin, C. A. M. Ritchie, L. Paton, M. C. W. Stewart, and staff at Wellcome Trust Clinical Research Facility, Edinburgh. Data Handling: E. Healy, H. Peterson, E. Crooks, L. Gardner, J. Hay, E. M. Kerracher, N. Kerracher, C. Maguire, A. Sloan, D. Thom, and L. C. McGoohan. Blood Assays and Pharmacy: A. Rumley, J. Patterson, G. Baxter, R. Spooner, E. Foley, and J. Carracher. Statistical Analysis: I. Butcher, G. S. McHugh, R. Lee, and G. D. Murray.
Funding/Support: The trial was funded by the British Heart Foundation and Chief Scientist's Office, Scotland. Bayer HealthCare provided the aspirin and placebo tablets and funds for packaging, dispensing, and some statistical analysis.
Role of the Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis and interpretation of the data; and preparation, review, or approval of the manuscript. The trial steering committee independently made all decisions on the conduct of the trial. A representative from Bayer HealthCare was permitted to attend steering committee meetings as an observer.