Author Contributions: Dr Brookhart had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Brookhart, Schneeweiss, Avorn, Bradbury, Winkelmayer.
Acquisition of data: Brookhart, Winkelmayer.
Analysis and interpretation of data: Brookhart, Schneeweiss, Avorn, Bradbury, Liu, Winkelmayer.
Drafting of the manuscript: Brookhart, Winkelmayer.
Critical revision of the manuscript for important intellectual content: Brookhart, Schneeweiss, Avorn, Bradbury, Liu, Winkelmayer.
Statistical analysis: Brookhart, Schneeweiss, Bradbury, Liu, Winkelmayer.
Obtained funding: Brookhart, Bradbury.
Study supervision: Brookhart, Schneeweiss, Avorn, Winkelmayer.
Financial Disclosures: Dr Brookhart reports having received investigator-initiated grant support from Amgen. He has participated, without receiving honoraria, in advisory boards of Amgen. Dr Schneeweiss reports that he is principal investigator of the Brigham and Women's Hospital DEcIDE Center on Comparative Effectiveness Research, funded by the Agency for Healthcare Research and Quality, and of the Harvard-Brigham Drug Safety and Risk Management Research Contract, funded by the US Food and Drug Administration. Dr Schneeweiss is a paid member of scientific advisory boards for HealthCore and ii4sm and has received consulting fees from WHISCON, RTI Health Solutions, the Lewin Group, and HealthCore. Dr Bradbury reports that he is an employee of Amgen Inc. Dr Winkelmayer reports receiving investigator-initiated grants from Amgen and GlaxoSmithKline. He has participated in advisory boards for AMAG Pharmaceuticals, Amgen, Roche, Genzyme, and Fresenius. No other disclosures were reported.
Funding/Support: This work was supported by an investigator-initiated contract from Amgen to Brigham and Women's Hospital that placed no restrictions on publications. Dr Brookhart is supported by a career development award from the National Institute on Aging (grant AG-027400). Dr Winkelmayer has received support including a Scientist Development Grant from the American Heart Association, a Norman S. Coplon Extramural Research Program Award from Satellite Healthcare Inc, support from the National Institutes of Health for unrelated projects.
Role of the Sponsor: The funding organization, Amgen, had no formal role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; or preparation of the manuscript. The contract gave the company 60 days to review the manuscript but placed no restrictions on publication. Dr Bradbury, as an employee of Amgen, provided feedback on the design, analysis, presentation, and interpretation of results, but final decisions about all aspects of the research project were made by the research team at Brigham and Women's Hospital. The final content of the manuscript was not subject to the approval of the sponsor.
Disclaimer: Data reported herein were supplied by the USRDS. Interpretation and reporting of these data are the responsibility of the authors and in no way should be seen as official policy or interpretation of the US government.
This article was corrected online for typographical errors on 4/20/2010.