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Letters | March 3, 2010

Aldosterone Antagonists in Patients With Heart Failure

Abdallah Fayssoil, MD

JAMA. 2010;303(9):833-835. doi:10.1001/jama.2010.185.

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To the Editor: Dr Albert and colleagues¹ studied the prescription of aldosterone antagonists for patients with heart failure (HF). Among the patients studied, 46% had nonischemic HF. It would be helpful to know whether the strength of the associations with aldosterone antagonist use found in the study differed between the nonischemic group and the ischemic group.

Because the use of aldosterone antagonists together with angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, or β-blockers can lead to hypotensive episodes,² I would like to know if the authors assessed whether this reaction could explain interruption in aldosterone antagonists use. Also, because new-onset arrhythmia may be influenced by the renin-angiotensin-aldosterone system,³ I would like to know whether the authors assessed correlation between onset of arrhythmia and aldosterone antagonist use.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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March 3, 2010

Aldosterone Antagonists in Patients With Heart Failure

Jalal K. Ghali, MD

JAMA. 2010;303(9):833-835. doi:10.1001/jama.2010.186.

March 3, 2010

Aldosterone Antagonists in Patients With Heart Failure—Reply

Nancy M. Albert, PhD, RN; Gregg C. Fonarow, MD; Adrian F. Hernandez, MD

JAMA. 2010;303(9):833-835. doi:10.1001/jama.2010.187.

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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 Credit^TM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 Credit^TM.

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Fayssoil A. Aldosterone Antagonists in Patients With Heart Failure. JAMA. 2010;303(9):833-835. doi:10.1001/jama.2010.185.

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