Author Contributions: Dr Briel had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Briel, Meade, Mercat, Slutsky, Brochard, Lamontagne, Guyatt.
Acquisition of data: Briel, Meade, Mercat, Brower, Talmor, Slutsky, Brochard, Richard, Bhatnagar, Guyatt.
Analysis and interpretation of data: Briel, Meade, Brower, Walter, Pullenayegum, Zhou, Cook, Brochard, Stewart, Guyatt.
Drafting of the manuscript: Briel, Meade, Walter, Guyatt.
Critical revision of the manuscript for important intellectual content: Meade, Mercat, Brower, Talmor, Slutsky, Pullenayegum, Zhou, Cook, Brochard, Richard, Lamontagne, Bhatnagar, Stewart.
Statistical analysis: Briel, Walter, Pullenayegum, Zhou.
Obtained funding: Briel, Meade, Guyatt.
Administrative, technical, or material support: Briel, Brower, Cook, Bhatnagar, Stewart.
Study supervision: Briel, Meade, Guyatt.
Financial Disclosures: Dr Mercat and Dr Richard reported receiving a research grant from General Electric. Dr Slutsky reported receiving consulting fees from Maquet Medical. Dr Brochard reported that his research laboratory has received research grants for the conduct of clinical trials during 2006, 2007, and 2008 from Dräger, General Electric, Maquet, Viasys, and Starmed. No other authors reported financial disclosures.
Funding/Support: The study was funded in part by a grant from the Canadian Intensive Care Foundation. Dr Briel is supported by a scholarship from the Swiss National Science Foundation (PASMA-112951/1) and the Roche Research Foundation. Dr Cook is a Canada Research Chair of the Canadian Institutes for Health Research.
Role of the Sponsor: The funding sources had no role in the design and conduct of the study; the collection, analysis and interpretation of the data; or the preparation, review, or approval of the manuscript.
Additional Contributions: We thank Jean Marie Chrétien, MSc (Centre Hospitalier Universitaire d’Angers, Angers, France), David Schoenfeld, PhD, and Katherine Husk, BSc (both of Massachusetts General Hospital, Boston), for assisting with data queries. We are grateful to Ramon Saccilotto, MD (Basel Institute for Clinical Epidemiology and Biostatistics, Basel, Switzerland), and Diane Heels-Ansdell, MSc (Department for Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada), for their technical assistance during data analysis. None of these persons received any compensation for their help with this study.