Author Contributions: Dr ten Berg had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: van Werkum, Ruven, Deneer, Harmsze, Hackeng, ten Berg.
Acquisition of data: Breet, van Werkum, Bouman, Harmsze.
Analysis and interpretation of data: Breet, van Werkum, Bouman, Kelder, Ruven, Bal, Deneer, van der Heyden, Rensing, Suttorp, Hackeng, ten Berg.
Drafting of the manuscript: Breet, van Werkum, Hackeng, ten Berg.
Critical revision of the manuscript for important intellectual content: Breet, van Werkum, Bouman, Kelder, Ruven, Bal, Deneer, Harmsze, van der Heyden, Rensing, Suttorp, Hackeng, ten Berg.
Statistical analysis: Breet, van Werkum, Kelder.
Obtained funding: van Werkum, Hackeng, ten Berg.
Administrative, technical, or material support: van Werkum, Bouman, Ruven, Deneer, Harmsze, Hackeng, ten Berg.
Study supervision: van Werkum, Ruven, Bal, Deneer, van der Heyden, Rensing, Suttorp, Hackeng, ten Berg.
Financial Disclosures: Dr van Werkum reports receipt of speakers bureau fees from Accumetrics and Siemens; and providing consultancy services for The Medicines Company. Dr ten Berg reports receipt of speakers bureau fees from Sanofi-Aventis, Lilly and Co, Bristol-Myers Squibb, and Merck and Co, Inc; and providing consultancy services for Sanofi-Aventis, Eli Lilly, Schering-Plough, and GlaxoSmithKline. The other authors reported no disclosures.
Funding/Support: Siemens Healthcare Diagnostics provided the Dade PFA Collagen/ADP Test Cartridge and Innovance PFA P2Y without charge.
Role of the Sponsor: Siemens Healthcare Diagnostics was not involved in the design and conduct of the study; collection, management, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript.
Previous Presentation: This study was presented as a late-breaking clinical trial at the American Heart Association Scientific Sessions, Orlando, Florida, November 14-18, 2009.
Additional Contributions: Innovance PFA P2Y is under development at the time of this publication and not available for sale.
We thank the independent committee that adjudicated all events: B. M. Swinkels, MD, St Antonius Hospital, Nieuwegein; W. Dewilde, MD, Catharina Hospital, Eindhoven; and F. W. A. Verheugt, MD, PhD, University Medical Center St Radboud, Nijmegen, the Netherlands. These individuals did not receive compensation in association with their work on this article.